NAA Services for Anti-Transglutaminase 3 (TG3) Antibodies

Creative Biolabs is a world leader in the field of NAA services. Based on our years of experience and advanced platform, we are confident in offering the best and most suitable natural autoantibodies (NAA) detection and analysis service. Here, we can provide anti-transglutaminase 3 (TG3) antibodies marker services for diseases diagnosis and therapeutic monitoring. Our experienced scientists will take part in every step of your program to accelerate your project development.

Background of Anti-transglutaminase 3 Antibodies

Transglutaminase 3 (TG3) is a soluble enzyme expressed predominantly in differentiating keratinocytes, corneocytes and hair follicles. It belongs to the transglutaminase family, which shows conservation especially of certain enzymatically relevant domains. Recently, TG3 is demonstrated to be an autoantigen in celiac disease, a gluten-dependent autoimmune disorder. Anti-tissue transglutaminase antibodies (anti-tTGs) are a kind of autoantibodies against the transglutaminase protein and show great potential as the diagnostic markers of coeliac disease. Currently, anti-tTGs can be classified according to 2 different schemes: transglutaminase isoform and immunoglobulin reactivity subclass (IgA, IgG) toward transglutaminases.

Fig.1 Epitope spreading from gliadin to TG2 or TG3.¹

The Role of Anti-TG3 in Celiac Disease

Celiac disease is an inflammatory disorder, commonly caused by an incorrect immune response to ingested wheat gluten (consist of gliadin and glutenin) and related cereal proteins in genetically predisposed individuals, leading to villous atrophy, crypt hyperplasia and lymphocytic infiltration in the small intestine. TG3 is an enzyme expressed in the epidermis and it is closely associated with, but not identical to TG2. The vast majority of celiac disease patients present circulating and intestinal autoantibodies against TG2 at the time of the diagnosis. In addition, TG3 autoantibodies have been identified in the serum of not only the untreated celiac disease but also of Dermatitis herpetiformis (DH) patients. Recently, a study has elucidated the significance of TG3 autoantibodies in celiac disease. Results showed that TG3 autoantibodies correlate with the age at diagnosis, the severity of clinical symptoms or histological inflammation or damage in celiac disease. In addition, gluten-dependency of TG3 autoantibodies can be evaluated with serial serum samples of celiac disease patients adhering to a gluten-free diet (GFD) treatment.

What Can We Do about NAA?

At present, we offer all kinds of NAA services with our well-established platforms and experienced scientists, including NAA detection, NAA profiling, NAA affinity measurement, NAA epitope mapping, and paratope mapping. In addition, a wide range of NAA products is also available for your choice. We also provide customized service to meet the needs of every customer.

Creative Biolabs is one of the forward-looking antibody service providers in the world. It leads to the development of the era while it offers the best service to the customers. We are pleased to provide high-quality NAA detection and analysis services to contribute to the success of your project. Our anti-TG3 antibodies marker services may greatly help the diagnosis of celiac disease. If you are interested in the service we provide, please feel free to contact us for more detail and information.

Reference:

Kaunisto, Helka, et al. "Antibody responses to transglutaminase 3 in dermatitis Herpetiformis: lessons from celiac disease." International Journal of Molecular Sciences 23.6 (2022): 2910.

For Research Use Only | Not For Clinical Use

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