Recombinant Human Complement Component C1s Protein-6 His tag(Cat#: CTP-029)
This product is a recombinant human Complement Component C1s protein (47 kDa A chain and 28 kDa B chain) with a C-terminal 6-His tag expressed in the mouse myeloma cell line, NS0. It is available for Enzyme Activity Assays.
Summary
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Specifications
| Expressed Host |
Mouse myeloma cell line, NS0 |
| Specie Reactivity |
Human |
| Target |
C1S |
| Molecule Mass |
47 kDa (A chain) & 28 kDa (B chain) |
| Purity |
>95% by SDS-PAGE under reducing conditions and visualized by silver stain |
| Endotoxin |
<1.0EU per 1µg (determined by the LAL method) |
| Formulation |
Tris, NaCl, CaCl2 and Glycerol |
| Applications |
Enzyme Activity Assays |
| Product Form |
Liquid |
| Storage |
Store at -20/-80°C. Aliquot to avoid repeated freezing and thawing. |
Protein Information
| Introduction |
Complement component 1s is a protein involved in the complement system. C1s is part of the C1 complex. C1s cleaves C4 and C2, which eventually leads to the production of the classical pathway C3-convertase. C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4. Cleavage of Arg-|-Ala bond in complement component C4 to form C4a and C4b, and Lys(or Arg)-|-Lys bond in complement component C2 to form C2a and C2b: the 'classical' pathway C3 convertase. |
| Alternative Names |
Complement Component 1, S Subcomponent; Complement Component 1 Subcomponent S; C1 Esterase; Basic Proline-Rich Peptide IB-1; Complement C1s Subcomponent; EC 3.4.21.42; EDSPD2 |
| Gene ID |
716 |
| UniProt ID |
P09871 |
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
