Recombinant Mouse C1qBP Protein-His tag(Cat#: CTP-012)

Name: Recombinant Mouse C1qBP Protein-His tag
SKU: CTP-012
Rating: 5 (1 reviews)

This product is a 25.0 kDa recombinant mouse C1qBP protein with a N-terminal His-Tag expressed in the E. Coli.

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Specifications

Expressed Host	E. Coli
Specie Reactivity	Mouse
Target	C1qBP
Molecule Mass	25.0 kDa
Purity	>95% as determined by SDS-PAGE
Endotoxin	<1.0EU per 1µg (determined by the LAL method)
Formulation	PBS, pH 7.4, containing 5% sucrose, 0.01% sarcosyl
Product Form	Lyophilized
Storage	Store at 2 to 8°C after reconstitution for short term (1-2 weeks). For long term storage, aliquot and store at -20 or -80°C. Avoid repeated freezing and thawing cycles.

Protein Information

Introduction	C1qBP is believed to be a multifunctional and multicompartmental protein involved in inflammation and infection processes, ribosome biogenesis, protein synthesis in mitochondria, regulation of apoptosis, transcriptional regulation and pre-mRNA splicing. It acts as an endothelial receptor for plasma proteins of the complement and kallikrein-kinin cascades at the cell surface. It is a putative receptor for C1q; specifically binds to the globular "heads" of C1q thus inhibiting C1; may perform the receptor function through a complex with C1qR/CD93. It is a high affinity receptor for kininogen-1/HMWK in complex with cytokeratin-1/KRT1. The secreted form of C1qBP may enhance both extrinsic and intrinsic coagulation pathways. It also involves in regulation of antiviral response by inhibiting DDX58- and IFIH1-mediated signaling pathways probably involving its association with MAVS after viral infection; HIV-1 replication, presumably by contributing to splicing of viral RNA; infection processes acts as an attachment site for microbial proteins, including Listeria monocytogenes internalin B and Staphylococcus aureus protein A; and replication of Rubella virus.
Alternative Names	Complement component 1 Q subcomponent-binding protein, mitochondrial; GC1q-R protein; Glycoprotein gC1qBP; Gc1qbp; C1qBP
Gene ID	12261
UniProt ID	O35658

For Research Use Only. Not for Diagnostic or Therapeutic Applications.