Folate is used to target folate receptors, which are often overexpressed in certain cancer cells, making it useful for targeted therapy.
Upon endocytosis and exposure to low pH, the reduced affinity between folate and FBP triggers disassembly, facilitating the intracellular release of drugs.
Freezing can damage the liposome structure, rendering them ineffective for their intended application.
It should be stored at 4°C and should never be frozen to maintain liposome integrity and stability.
Hydrophobic ligands or peptides should be solubilized in DMSO or DMF, ensuring that the volume does not exceed 5%.
Confocal laser scanning microscopy (CLSM) results of Exo and EL in A2780 cells, B16 cells, and CT26 cells.
This article explores the enhanced therapeutic potential of hybrid exosomes loaded with paclitaxel (PTX) for cancer treatment. The researchers designed a tumor-targeted hybrid exosome vesicle (EL) composed of exosomes and folate liposomes for the delivery of PTX. Subsequently, they evaluated its uptake in cancer cells (A2780, B16, and CT26 cells). The results showed that exosomes exhibited a certain level of cellular internalization, while the fusion with folate liposomes significantly enhanced target recognition and uptake capabilities. In this study, folate liposomes were crucial for selectively targeting cancer cells and promoting improved therapeutic efficacy. This targeting strategy highlights the potential of folate liposomes in enhancing treatment outcomes.
Wang, Xuan, et al. "Enhanced Therapeutic Potential of Hybrid Exosomes Loaded with Paclitaxel for Cancer Therapy." International Journal of Molecular Sciences 25.7 (2024): 3645.
Distributed under Open Access license CC BY 4.0, without modification.
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