Delivery System Based on CPP

Current diseases therapies utilizing the traditional small molecular agents would result in inadequate or adverse effects due to the lack of selectivity of cancer cells over normal cells, the rapid clearance of these water-soluble small molecular agents from the bloodstream, and the drug resistance commonly exhibited by tumor cells. Therefore, new approaches are required to prevail over these obstacles. Cell-penetrating peptides (CPPs) represent a promising delivery system used in module delivery. Based on our years of experience and advanced platform, Creative Biolabs is confident in offering the best and most suitable targeted delivery services based on CPP. Our experienced scientists will take part in every step of the research design and execution to accelerate your project development.

CPP

CPPs are short peptides that promote cellular intake/uptake of a variety of molecules such as nanosize particles, small chemical molecules and large fragments of DNA. The "cargo" is related to the peptides either through chemical linkage via covalent bonds or through non-covalent interactions. CPPs typically have an amino acid composition that either contains a high relative abundance of positively charged amino acids or has sequences that contain an alternating pattern of polar/charged amino acids and non-polar, hydrophobic amino acids. A third class of CPPs is the hydrophobic peptides with only a polar residues and low net charge or have hydrophobic amino acid groups that are critical for cellular uptake.

Fig.1 Mechanisms of the intracellular entry of CPPs.¹

Delivery System Based on CPP

It has been widely studied by researchers recently that CPPs can facilitate the intracellular delivery of various cargoes without causing any cellular damage. They are able to penetrate into a wide variety of mammalian cells independent of tissue or organism types. Furthermore, some CPPs can even promote targeted delivery to subcellular structure such as cell nucleus, mitochondria, lysosome and cytosol. Cargoes that have been delivered successfully by CPPs include small molecules, peptides, proteins, nucleic acids, quantum dots, polysaccharides, liposomes and nanoparticles.

Fig.2 Delivery System Based on CPP.²

The CPPs enter the cells by various mechanisms and thereby provide the possibility to transfer cargoes. The relatively short peptides composed of up to 40 amino acids have demonstrated to carry several times larger molecules without impact on their membrane penetration ability. These promising attributes render the increasing use of CPP in modern drug delivery systems.

Features of Our Targeted Delivery Services

• High cell penetration efficiency
• Long plasma half-life
• Target-specific recognition
• Minimum side effects
• Fast turnaround time
• Competitive pricing

Creative Biolabs is a forward-looking services provider who leads the development of the era while offering the best service to customers around the world. Creative Biolabs is pleased to provide high-quality targeted delivery services to contribute to the success of your project. Our targeted delivery services based on CPP may help the developmment and optimization of various therapeutic strategies for our worldwide customers. If you are interested in the service we provide, please feel free to contact us for more detail and information.

References

1. Zhou, Meiling, et al. "The role of cell‐penetrating peptides in potential anti‐cancer therapy." Clinical and Translational Medicine 12.5 (2022): e822.
2. Yokoo, Hidetomo, Makoto Oba, and Satoshi Uchida. "Cell-penetrating peptides: Emerging tools for mRNA delivery." Pharmaceutics 14.1 (2021): 78.

Our services are For Research Use Only. We do not provide services to individuals.