Targeting Adipose Tissue

Using our own innovative technology platform, Creative Biolabs has developed tissue-targeting module sets that recognize specific tissues including heart, liver, spleen, lung, kidney, bone, brain, prostate, adipose tissue, eye and joint. As an acknowledged targeted delivery service provider, Creative Biolabs offers adipose tissue-targeted delivery services and products to help our customers obtain ideal results contributing to research and projects successfully.

Adipose tissue regulates numerous physiological processes and is essential for handling excess calories. Dysfunction of adipose tissue in obese humans is tightly associated with disrupted metabolic homeostasis and increased risk for metabolic, cardiovascular and chronic inflammatory diseases, such as obesity, dyslipidemia, type 2 diabetes (T2DM), nonalcoholic fatty liver disease (NAFLD), coronary heart disease, hypertension and stroke. Therefore, pharmacological interventions focused on maintaining or improving adipose tissue health form the basis for both prophylactic and therapeutic interventions in metabolic and cardiovascular disease. As an active endocrine organ, some adipocyte-derived secretory proteins and their receptors represent promising pharmacological targets.

Fig.1 Adipose tissue resident and infiltrating immune cells activity in health and disease.¹

Targeted Drug Delivery

Nanoparticles have proven to be effective in the treatment of particular locations of the body through the targeted delivery system. Nano drug molecules bind to proteins found in the lining of the blood vessels that surround adipose tissue or binds to receptors on the outer surface of the adipose tissue and burn it. For example, human adipose tissue is highly vascularized and poses anti-angiogenic properties. A pro-apoptotic peptide ligand bound with significant nanoparticle/nanocarrier which is delivered to obese adipose tissue causes depletion of endothelial cells increasing cell apoptosis.

Fig.2 Summarizing schematic illustration of fatty liver/adipose tissue dual-targeting PBP-NPs containing HO-1 inducers for the treatment of obesity, obesity-induced type 2 diabetes, and nonalcoholic steatohepatitis.²

Example of Targeted Delivery System

The primary function of white adipose tissue (WAT) is to store energy, whereas brown adipose tissue (BAT) generates heat through energy expenditure. Thus, transforming WAT into BAT is of tremendous interest for disease treatment. Scientists developed an angiogenesis-targeted nanomedicine approach to deliver adipose tissue browning agents and simultaneously stimulate angiogenesis in WAT. The resulting high vascular density allows greater drug accumulation in WAT, which produces a positive feedback loop, accelerating the transformation of WAT into BAT. Meaningfully, this strategy of combined targeted nanomedicine for angiogenesis stimulation could potentially open the way toward effective treatments for obesity and other metabolic diseases.

What Can We Do for You?

Nanoparticles targeting the adipose tissue have shown high potential to offer a wide variety of diagnostic imaging and therapeutic applications in related diseases. With years of experience in the field of targeted delivery, Creative Biolabs provides high-quality services targeting adipose tissue for clients all over the world. Please don't hesitate to contact us for more information.

References

1. AlZaim, Ibrahim, et al. "Adipose tissue immunomodulation: a novel therapeutic approach in cardiovascular and metabolic diseases." Frontiers in Cardiovascular Medicine 7 (2020): 602088.
2. Hong, Juhyeong, and Yong‐Hee Kim. "Fatty Liver/Adipose Tissue Dual‐Targeting Nanoparticles with Heme Oxygenase‐1 Inducer for Amelioration of Obesity, Obesity‐Induced Type 2 Diabetes, and Steatohepatitis." Advanced Science 9.33 (2022): 2203286.

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