Targeting Kidney
Creative Biolabs has persisted for many years in the field of targeted delivery, and we are committed to developing the proper tissue targeting carrier and module delivery systems for both research and therapeutic use. A variety of targeting modules including peptides and antibody fragments have been utilized with nanoparticles to target kidney-specific cells, such as the glomerular mesangial cells, glomerular endothelial cells, and tubule cells. Creative Biolabs now provides kidney targeting products and high-quality kidney delivery strategies for our clients all over the world.
Kidney is the vital organs of the humoral regulation and maintains the nutrients and metabolites of the body balanced. kidney dysfunction may result in chronic kidney disease, which has been generally acknowledged as a serious problem affecting public health. Therapies such as dialysis or kidney transplantation are generally expensive and may cause various severe side effects. Thus, developing new therapeutic strategies for treating patients with kidney disease is necessary and crucial. Selective targeted delivery of drugs to kidney with the guidance of specific targeting module may increase kidney effectiveness and simultaneously reduce extra kidney effects.
Fig.1 Schematic illustration of nanocomplex, which tends to deliver drugs safely to the kidney.1
Cell-type Specific Targeting Strategy
The ability to target specific cell types within the kidneys could be extremely useful for active targeting. Strategies that target different kidney cells can give researchers a wide selection when developing diagnostic or therapeutic strategies for renal diseases that affect particular kidney cell types.
Fig.2 Schematic of the mechanism of targeted drug delivery in the kidney.1
Many common genetic diseases affect podocytes such as the Alport syndrome, membranous nephropathy, and segmental glomerular sclerosis. The particular αvβ3 integrin expressed on podocytes plays a role in kidney viral infection, making it a candidate for facilitating cellular uptake.
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Glomerular endothelial cell barrier and basement membrane
The glomerular endothelial cells and podocytes secrete a layer of the extracellular matrix which forms the glomerular basement membrane, composed of collagen IV, laminin, and proteoglycans. Peptides that can recognize the glomerular endothelial markers of kidney have already been predicted based on the innovative model. To enhance the tissue-specific interactions of targeting peptides, Suzuki et al. linked the carbohydrate-modified Arg-vaso-pressin (AVP) peptide (CYFQNCPRG) to a variety of sugars via an octamethylene spacer group. The results indicate that the renal uptake of complex forms takes place from the blood via the basolateral membrane.
Tubular epithelial cells are highly susceptible to injury and are regarded as an important cellular target for therapies intended to treat proinflammatory and fibrogenic tubular injury. Bidwell et al. modified the targeting module with an elastin-like polypeptide (ELP) to specifically target the tubule. Besides, many targeting moieties identified by phage display such as G3-C12 peptide were able to accumulate in the kidneys via renal proximal tubule cell reabsorption only three minutes post-injection.
What Can We Do for You?
Creative Biolabs is capable of providing either individual targeting modules or different kinds of module-payload/ carrier conjugates targeting kidney. Moreover, a wide spectrum of corresponding products are available for you. Delivery systems with the targeting module show great promise for the treatment of kidney disease in a clinical setting and can be an effective strategy in future studies. Creative Biolabs offers Kidney-targeted delivery services regarding diseases, subcellular organelles, and infectious microorganisms. If you are interested in our services, please contact us for more information.
Reference
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Merlin, JP Jose, and Xiaogang Li. "Role of nanotechnology and their perspectives in the treatment of kidney diseases." Frontiers in Genetics 12 (2022): 817974.
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