Subcellular Organelles Targeting Services

Active tumor-targeting approaches using specific ligands have drawn considerable attention over the years. However, a single ligand often fails to simultaneously target the cancer cell surface and subcellular organelles. Here, module targeting cell surface and subcellular organelle could be conjugated together onto different module delivery systems for the delivery of therapeutic drug into a specific intracellular site. With our extensive experience and advanced platform, Creative Biolabs now provides a wide range of targeted delivery services against various organelles candidates for disease diagnosis and treatment.

Nanoparticle accumulation in cancer cells does not necessarily lead to an efficient therapeutic outcome. Nanomedicines seem to lose their targeting capacity intracellularly before mediating their effect in a specific target subcellular organelle (e.g., the nucleus or mitochondria). The other way around, a single module targeting subcellular organelle might only achieve suboptimal therapeutic effects because subcellular-targeting module is mostly positively charged and exhibit no selectivity for specific organs, tissues or cell types. Thus, coating the carrier surface with both a subcellular-targeting module and a tumor cell-targeting module is an ideal choice. In this regard, targeting module that is active in subcellular organelles such as mitochondria, nucleus, cytosol, lysosome and Golgi are being developed.

Fig.1 Schematic illustration showing active cellular (left) and subcellular (right) targeting of NP-drug formulations.¹

Upon most occasions, module targeting subcellular organelle cannot overcome both cellular and subcellular barriers at the same time. Besides subcellular-targeting module, Creative Biolabs also provides modules that exert tumor cell and subcellular organelle dual-targeting ability and different module-cargo products through a specific delivery system according to your demands. Such a dual-module approach could show promise for synergistic cancer therapy.

Fig.2 Schematic illustration of the mitochondrion-specific dendritic lipopeptide liposomes L-G2R-DA for cancer therapy.²

Subcellular delivery involves delivering a drug in its active form to its target site of action inside the cell. For example, organelle-specific cell penetrating peptides (CPPs) are under rapid development, which provides an approach to target therapeutic agents not only to the cell, but also to a specific subcellular compartment to achieve optimal activity and reduce non-specific effects. So far, the nucleus and the mitochondria have been successfully targeted with CPPs for gene therapies and anti-cancer chemotherapies.

What Can We Do for You?

Equipped with our well-established module delivery systems and experienced scientists, we can provide either individual targeting modules or different kinds of module-payload/ carrier conjugates targeting a specific subcellular organelle. A wide spectrum of corresponding products are available for your choice.

Features of Our Services Including but Not Limited to:

• Various subcellular organelles targets
• Different combinational strategy
• Customized products
• Fast turnaround time
• Competitive pricing
• Personalized services

Subcellular-targeted delivery is a promising new approach for enhancing and controlling pharmacological activities of drugs acting on intracellular targets. Along with years of experience in the field of targeted delivery, Creative Biolabs is confident in offering customized targeted delivery products and services to meet clients’ specific needs. If you are interested in our service, please do not hesitate to contact us for more details.

References

1. Nag, Okhil K., and James B. Delehanty. "Active cellular and subcellular targeting of nanoparticles for drug delivery." Pharmaceutics 11.10 (2019): 543.
2. Jiang, Lei, et al. "Mitochondrion-specific dendritic lipopeptide liposomes for targeted sub-cellular delivery." Nature communications 12.1 (2021): 2390.

Our services are For Research Use Only. We do not provide services to individuals.