Targeting Fibrosarcoma
To date, a large number of modules specifically targeting various human diseases were discovered, which is warranted to provide substantive feasibilities for drug delivery and imaging in terms of novel targeted therapeutics and diagnostics. Creative Biolabs is a world leader in the field of providing targeted delivery services. Based on our years of experience and first-class module delivery platform, we are confident in offering the best and most suitable delivery systems to meet your requirements. Here we can provide targeted delivery services targeting fibrosarcoma. Our experienced scientists will take part in every step of your program to accelerate your project development.
Fibrosarcoma
Fibrosarcoma (fibroblastic sarcoma) is a malignant mesenchymal tumour developed from fibrous connective tissue and characterized by the presence of immature proliferating fibroblasts or undifferentiated anaplastic spindle cells in a storiform pattern. It is commonly found in males aged 30 to 40. It occurs in fibrous tissues of the bone and invades long or flat bones such as femur, tibia, and mandible. It also presents in periosteum and overlying muscle. In adult-type, patients with fibrosarcoma are usually adults aged thirty to fifty-five years, often emerging with pain. Generally, males have a higher incidence of fibrosarcoma than females in adults. In infantile-type, fibrosarcoma is usually congenital. Infants have the fibrosarcoma generally in the first two years of their life. During the fibrosarcoma, tumour cells may resemble mature fibroblasts which can secrete collagen, with rare mitoses. Immature blood vessels involved in the bloodstream metastasizing.
Fig.1 Fibrosarcoma.
Delivery System Targeting Fibrosarcoma
To date, many targeted delivery systems have been used in cancer treatment. For example, the liposomes with several modifications on its surface can be used in the targeted delivery system to treat fibrosarcoma. Liposomes with cyclic Asn-Gly-Arg (cNGR) peptide targeting CD13 were formulated with lysogenic lipids-loaded doxorubicin for the potential treatment of human fibrosarcoma. Affinity for CD13+ cancer cells was improved 10-fold for both the cyclic and linear NGR when presented in a multivalent fashion on the surface of lysolipid-containing temperature sensitive liposomes (LTSL). These results demonstrated that the targeted delivery system based on liposomes combining with the specific peptide can be used in fibrosarcoma treatment.
Enzyme responsive delivery systems are also used for fibrosarcomas treatment. Matrix metalloproteinase 2 (MMP-2) responsive nanoparticles are covered by a shell of long PEG chains on their surface. These chains can increase the particle size while protecting it from serum proteins. The particles are conjugated to the PEG chains with MMP-2 sensitive bonds, upon the nanoparticle formulation enters the tumor interior, the bonds are cleaved resulting in the decreasing of the particle size and allowing for better interactions of the particle with cancer cells. Using this strategy, a siRNA-loaded nanoparticle can significantly improve anti-tumor activity targeting fibrosarcomas.
Fig.2 Overview of cancer targeting strategies from the cells to the clinics. (Jin, 2014)
What Can We Do for You?
Creative Biolabs is one of the forward-looking targeted delivery service providers who offers the custom service to clients around the world. We are pleased to provide high-quality targeted delivery services to contribute to the success of your project. Our services targeting fibrosarcoma may help the treatment of this disease for our worldwide academic and industrial customers. If you are interested in our service, please feel free to contact us for more detail and information.
Reference
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Jin, S. E.; et al. Targeted delivery system of nanobiomaterials in anticancer therapy: from cells to clinics. Biomed Res Int, 2014, 2014(2014), 814208.
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