Targeting Lymphoma

Despite the effectiveness of chemical small molecular in disease treatment, the clinical use of chemicals is compromised by its short biological half-life, nonselective in vivo distribution, development of drug resistance, and, most seriously, the severe toxicity. In recent years, the targeted delivery system displays its advantages in drug delivery and bioimaging, having been widely used in clinics and research. Creative Biolabs has advanced module delivery systems platforms and extensive experience in targeted delivery services. Now we provide high-quality lymphom- targeted delivery services for our clients all over the world. With combined expertise in protein chemistry, immunology, and molecular biology, our scientific team can help you with every step of the development process, from design to validation. Our state-of-art technical platform and professional scientist team will be helpful for your projects.

Lymphoma

Lymphoma is a kind of blood cancer that originates from lymphocytes. Signs and symptoms commonly include enlarged lymph nodes, fever, drenching sweats, unintended weight loss, itching, and constantly feeling tired. The enlarged lymph nodes usually do not present pain. Another typical symptom is sweating at night. Lymphomas have dozens of subtypes and the two primary categories of lymphomas are Hodgkin's lymphomas (HL) and the non-Hodgkin lymphomas (NHL). The other categories as types of lymphoma are multiple myeloma and immunoproliferative diseases. In general, about 90% of lymphomas are NHL. Lymphomas and leukemias are a part of the extensive group of tumors of the hematopoietic and lymphoid tissues. Main treatment approaches of these diseases are chemotherapy, radiation therapy, targeted therapy, and surgery.

Fig.1 Lymphoma.

Delivery System Targeting Lymphoma

To date, some drug delivery systems have been widely used in the therapy of lymphoma. For instance, the folic acid (FA)-decorated systems were found to be preferentially internalized on the B-cell lymphoma cell line which is reported to express the folate receptor. FA-decorated vincristine (VCR)-loaded system was designed for the targeted lymphoma treatment. Besides, in vitro and in vivo detections have evaluated the anti-B-cell lymphoma effect of the VCR-loaded lipid-polymer hybrid nanoparticles (LPNs). Results showed a precisely targeted effect in the delivery to B-cell lymphoma cells and the highest anti-tumor effect in murine-bearing lymphoma xenografts. Thus, FA-VCR/LPNs could be acted as an excellent system for lymphoma therapy to achieve targeted delivery of VCR, bring about an outstanding therapeutic effect to treat lymphoma, and also decrease the systemic toxicity.

Fig.2 Novel targeted therapeutic classes in follicular lymphoma (FL).¹

Another study found that the PEG-derivatized NLG polymer can be used for the delivery of doxorubicin (DOX) in the treatment of leukemia. The DOX-loaded micelles were self-assembled, which have a spherical shape with a uniform size of ∼120 nm. The administration of DOX-loaded PEG-Fmoc-NLG micelles into murine lymphocytic leukemia cells (A20) results in significant cytotoxicity that was comparable to that of free DOX. For in vivo studies, significantly improved antitumor activity was observed for the DOX/PEG-Fmoc-NLG group compared with Doxil or the free DOX group in an A20 lymphoma mouse model. In addition, DOX was loaded in natural platelets for the treatment of lymphoma. Results suggested that DOX was loaded into platelets with high drug loading and encapsulation efficiency. The growth inhibition of lymphoma Raji cells was promoted by DOX-platelet. Thus, platelets can serve as a potential drug delivery system to deliver DOX for clinical treatment of lymphoma.

What Can We Do for You?

As one of the most professional service providers in targeted delivery, Creative Biolabs provides optimized deliver systems  targeting lymphoma, and we promise to offer the most comprehensive approach in a timely and cost-effective manner. We also provide customized services to meet the specific demand of our clients. Please contact us for more information.

Reference

1. Nath, Karthik, and Maher K. Gandhi. "Targeted treatment of follicular lymphoma." Journal of personalized medicine 11.2 (2021): 152.

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