Technology
In recent years, there has been a steadily growing interest in using targeted delivery systems in different biomedical applications such as targeted drug delivery system and non-invasive bioimaging and biosensors. Besides the expertise in antibody design and engineering, Creative Biolabs is also dedicated to the areas of targeted delivery services for disease treatment and diagnostics by developing customized targeting modules and deliver systems with various advanced technology. With over 10 years of experience in bio-conjugation field and high-resolution imagery, Creative Biolabs has the most comprehensive knowledge to provide customers with targeted delivery services from design to the production of fully conjugated peptides or other proteins and probes.
Technologies Introduction
Targeted delivery is a method of delivering medication to patient in a manner that increases the concentration of the medication in the targeted part of the body relative to others. This means of delivery employs special carrier-mediated drug delivery to combat the downfalls of conventional drug delivery. These carriers are loaded with drugs and directed to specific parts of the body where there is solely diseased tissue, thereby avoiding interaction with healthy tissue. The purpose of a targeted delivery system is to prolong, localize and target the diseased tissue with a protected drug. The commonly used drugs are small chemical molecules or biologics. The latter, often including the antibodies, peptides and scaffold proteins, are actively developed and evaluated in recent years. With the ability to target the antigens, these biologics are termed as targeting modules in the targeted delivery system.
Fig.1 Scheme of drug loading options in targeted drug delivery. (Mcnamara, 2017)
An antibody, also referred to as an immunoglobulin (Ig), is a large Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses. The antibody recognizes a unique antigen via the Fab's variable region, which has been used widely in cancer and other disease treatments. Peptides are a series of short chains of amino acid monomers linked by peptide (amide) bonds. Peptides can be served as pharmacological agents and have become an attractive therapeutic approach. Besides, some peptide-based drugs are progressing in clinical development in oncology. Scaffold proteins are a type of important regulators of many key signaling pathways--they can interact and/or bind with multiple members of a signaling pathway. They are involved in regulating signal transduction and helping localize pathway components to specific areas of the cell, such as plasma membrane, cytoplasm, nucleus, Golgi, endosomes, and mitochondria.
Despite the successes and early promising results from the use of peptides or scaffold proteins as drugs, the limitations are also inevitable, i.e. peptides are usually subject to rapid clearance and a short half-life. Therefore, it is essential to extend the stability and improve pharmacokinetic (PK) properties of these targeting modules by a variety of delivery systems. At present, Creative Biolabs has developed many strategies for the delivery system, including those based on Fc fusion protein, albumin, FULL NAME OF CPP (CPP), liposome, graphene oxide, hyaluronic acid, elastin-like polypeptide and peptide-SNAP-tag fusion protein.
Fig.2 Liposomes functionalized for targeted drug delivery.
Features of Our Services
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Seasoned scientist
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First-rate platform
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High efficiency and timely delivery
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Cost-effective
As the newer generation of immunotherapy, targeted delivery therapy such as antibody-drug conjugates (ADCs) and peptide-drug conjugates (PDCs) is meticulously constituted bio-macromolecules with high potential in the treatment of cancer and various other diseases. The technical platforms at Creative Biolabs are ready to serve the diverse needs of our clients and we can tailor specific targeted delivery service to fit your timeline and R&D budget. Please contact us for more information and a detailed quote.
References
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McNamara, Karrina, and Syed AM Tofail. "Nanoparticles in biomedical applications." Advances in Physics: X 2.1 (2017): 54-88.
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