Targeting Lung

With greater interest in the delivery of targeting module-based drugs or other bio-molecules to lung for topical and systemic activity, Creative Biolabs has developed a wide range of module delivery systems deftly integrated with our innovative and diversified targeting module. We are capable of offering clients both individual targeting module-payload conjugate services and comprehensive delivery strategies design and development service.

Successful drug development requires not only the optimization of pharmacological specificity and potency, but also a method for efficient drug delivery to the target site. Lung-targeted drug delivery to specific disease sites would increase the efficacy of drugs for lung disease, thereby reducing the chances for side-effects in other healthy tissues and organs. Tissue-specific markers have revealed prospective molecular targets that may be used to direct therapies to the lung. Besides the molecular targets, various carriers can be employed to provide active targeting with the help of targeting modules.

Fig.1 Schematic representation of CA IX-decorated TPL liposomes for lung cancer-targeted therapy by pulmonary delivery.¹

Cell-type Specific Targeting Strategy

The ability to target specific cell types within the lungs has been prove to be extremely useful for both disease treatment and for prevention and/or diagnosis. Specific to lung, much of the cell-type specific targeting work could be accomplished by targeting to alveolar macrophage (AM) and lung cancer cells.

Fig.2 Promising therapies targeting lung cancer stem cell markers.²

Liposomes and microspheres are generally engulfed by AMs owing to their particulate nature and precoating particles with bovine gamma-globulin, human fibronectin, and gelatin enhances phagocytosis and dense particles of <5 µm tend to be engulfed by AMs. Liposomes tend to be less stable after phagocytosis, leading to a rapid discharge of their contents. Receptors for transferrin, lactoferrin, immunoglobulins, interleukin-2, and granulocyte-macrophage colony-stimulating factors are present on AM cell membranes. This mechanism could be used for targeting module (such as peptides, small scaffold proteins) to AMs. Additionally, several receptors are overexpressed in lung cancer cells including folic acid and epidermal growth factor (EGF), and this phenomenon has also been harnessed to targeting lung cancer cells.

What Can We Do for You?

Based on our well-established module delivery systems and targeting module, we can provide either individual targeting modules or different kinds of module-payload/ carrier conjugates targeting lung. A wide spectrum of corresponding products are available for your choice.

In brief, the targeted delivery system based on specific markers on cells within lung can be used to achieve more efficient drug delivery to lung. We have developed various modules that home selectively to the target site by the binding module to markers selectively expressed in lung. If you take an interest in our lung-targeted delivery services, please don't hesitate to contact us for more information.

References

1. Lin, Congcong, et al. "Pulmonary delivery of triptolide-loaded liposomes decorated with anti-carbonic anhydrase IX antibody for lung cancer therapy." Scientific reports 7.1 (2017): 1097.
2. Zheng, Yue, et al. "Lung cancer stem cell markers as therapeutic targets: an update on signaling pathways and therapies." Frontiers in Oncology 12 (2022): 873994.

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