Targeting Heart

The strategies of heart-targeted drug delivery refer to the direction of active agents and their carriers into the affected tissue with minimal effects on surrounding healthy tissues after systemic administration. The efficacious delivery of drugs to the heart is an important treatment strategy for various heart diseases. Having worked in the field of organ-targeted delivery for many years, Creative Biolabs has developed innovative and diversified organ-targeted modules. Now, armed with various module delivery systems, we provide our customers with different heart-targeted drug delivery systems, including dendrimers, liposomes, polymer-drug conjugates, microparticles, nanoparticles, micelles and so forth.

The success of nanocarriers for delivering drugs to therapeutic sites in the heart mainly depends on specific target sites, appropriate drug delivery carriers and effective targeting ligands. Successful targeted drug delivery suggests the specific deposition of a drug in the heart with minimal effects on other organs after administration. At present, heart-targeted drug delivery systems include dendrimers, liposomes, polymeric drug conjugates, microparticles, nanoparticles (silica nanoparticles, magnetic nanoparticles, magnetic nanoparticles, Pt-modified TiO2 nanoparticles, polymeric nanoparticles), micelles and microbubbles.

Fig.1 Illustration of nanoparticle-based drug delivery for the treatment of myocardial injuries.¹

A successful design for heart-targeted nanoscale drug delivery systems is mainly based on two parameters. First, heart-target vehicles play a crucial role in protecting therapeutics from immediate degradation in the blood, thus suitable heart-targeted drug carriers need to be selected. Second and perhaps more importantly, an appropriate targeting moiety is needed to ensure the specific interaction of the nanocarriers with the complementary molecules on the surface of the targeted cells in the heart. The heart-homing module may provide a means of targeting diagnostic and therapeutic agents to the heart in that way. Numerous reports have proved the application of heart-targeted modules.

Fig.2 Illustrative summary of cardiac fibrosis triggers, signaling pathways, biomarkers, and therapies.²

What Can We Do for You?

Equipped with our well-established module delivery systems and experienced scientists, we can provide either individual targeting module or different kinds of module-payload/ carrier conjugates targeting heart. A wide spectrum of corresponding products are also available for you.

By employing innovative targeting modules to appropriate carrier, Creative Biolabs offers a full range of high-quality heart targeted delivery services for our worldwide clients. To get more information and a detailed quote, please feel free to contact us.

References

1. Li, Dong, et al. "Nanoparticle Based Cardiac Specific Drug Delivery." Biology 12.1 (2023): 82.
2. Bertaud, Alexandrine, et al. "Signaling pathways and potential therapeutic strategies in cardiac fibrosis." International Journal of Molecular Sciences 24.2 (2023): 1756.

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