Delivery System Based on Hyaluronic Acid

Hyaluronic acid (HA) is stable in the serum-containing environment and can serve as a delivery system. The novel HA based delivery vehicles are highly specific and presenting good delivery efficiency. HA and its derivatives have been applied widely in drug delivery and imaging. Creative Biolabs is an undisputed global leader in the custom targeted delivery system field, and provides targeted delivery services for a wide variety of diseases treatment and detection. Here we offer high-quality targeted delivery services based on HA. Our experienced scientists will take part in every step of the research design and execution to accelerate your project development.

Hyaluronic Acid

HA, also known as hyaluronan, is an anionic, nonsulfated glycosaminoglycan distributed widely in connective, epithelial, and neural tissues. It is distinct among glycosaminoglycans in that it is nonsulfated, forms in the plasma membrane instead of the Golgi apparatus, and can be very large. Human synovial HA averages about 7 million Da per molecule with about twenty thousand disaccharide monomers. As one of the major modules of the extracellular matrix, hyaluronan contributes significantly to cell proliferation and migration, and may also take part in the progression of some malignant tumors. HA plays important roles in a variety of physiological processes including cancer, wound repair, inflammation, granulation, cell migration, skin healing and fetal wound healing. FDA has approved HA for medical uses. The first hyaluronan biomedical product, Healon, was developed in the 1970s and was approved for use in eye surgery.

Fig.1 Biomedical applications of HA.¹

Delivery System Based on Hyaluronic Acid

HA is a natural polysaccharide and it possesses good biocompatibility and degradability. HA and its derivatives have been used as sustained-release carriers for drugs, which can delay the release of drugs and have a long-acting effect. They can deliver a variety of drugs such as proteins, nucleic acids and anti-tumor drugs. HA and its derivatives can specifically recognize multiple receptors on the cell surface, which leads to emerging studies and applications of HA as tumor-targeted drug delivery systems.

Fig.2 Chemical structure of HA and the hypothesized procancer (promoting cancer growth) and anticancer (preventing cancer growth) activity of HA with different molecular weights and its application.²

HA and its derivatives can be used as carriers for a number of drug delivery systems. Based on different forms of carriers, they have been divided into different drug delivery systems such as nanoparticle, gel, cationic polymer for gene drug delivery, nano-emulsion, polyelectrolyte microcapsule, microsphere, film agent delivery system and so on. Thus, the research progresses on different forms of tumor-targeted drug delivery systems based on HA were pointed, including HA-drug conjugate, amphiphilic derivative of HA, HA surface-modified delivery system, and gene drug with HA.

Advantages of Our Targeted Delivery Services

• Highly biodegradable and biocompatible
• Nontoxic and non-immunogenic
• Sustained release
• Enhanced permeability
• High solubility and stability

Along with years of rich experience in the field of targeted delivery system discovery, Creative Biolabs has successfully finished lots of projects for our customers all over the world. Currently, we provide high-quality targeted delivery services based on HA. We are now confident in offering the customized proposal to meet your specific needs. If you are interested in our service, please do not hesitate to contact us for more details.

References

1. de Oliveira, Juliana Davies, et al. "Genetic basis for hyper production of hyaluronic acid in natural and engineered microorganisms." Microbial cell factories 15.1 (2016): 1-19.
2. Fu, Chao-Ping, et al. "Hyaluronic Acid-Based Nanocarriers for Anticancer Drug Delivery." Polymers 15.10 (2023): 2317.

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