Delivery System Based on Liposome

A variety of substances for diagnostic imaging and therapy of various diseases may have either severe adverse effects or insufficient effectiveness in vivo due to the nonspecific uptake. By targeting delivery of drugs or imaging agents onto the specific sites, the efficiency may be significantly enhanced. Scientists at Creative Biolabs are experts in targeted delivery system research. We have a series of innovative and advanced platforms to provide fast and convenient targeted delivery services for our worldwide customers. Currently, we can provide affordable, high-quality targeted delivery services based on liposome for diseases diagnosis and therapeutics with unbeatable rapid turnaround time.

Liposome

Liposomes, first described by British haematologist Dr Alec D Bangham FRS in 1961, are spherical vesicle having at least one lipid bilayer. These molecules have a head group and a tail group. The head is attracted to water, whereas the tail is made of a long hydrocarbon chain and is repelled by water. Liposomes often consist of phospholipids, especially phosphatidylcholine, and other lipids, such as egg phosphatidylethanolamine, as long as they are compatible with lipid bilayer structure. The primary types of liposomes are multilamellar vesicle with several lamellar phase lipid bilayers, small unilamellar liposome vesicle (SUV, with only one lipid bilayer), large unilamellar vesicle (LUV), and cochleate vesicle. Multivesicular liposomes are considered as the less desirable form in which one vesicle has one or more smaller vesicles. The liposomes can be used as a vehicle (delivery system) for the administration of nutrients and pharmaceutical drugs.

Fig.1 Liposomes.¹

Delivery System Based on Liposome

Liposomes can deliver drugs for cancer and other diseases by encapsulating drugs inside. The bilayered vesicle serving as an efficient carrier for drugs, vaccines, diagnostic agents and other bioactive agents has resulted in rapid development in the liposomal drug delivery system. It can also reduce cytotoxicity of many potent therapeutic agents for the site-avoidance or site-specific drug targeting therapy. Liposomes can be used as a therapeutic tool in many fields like tumor targeting, genetic transfer, immunomodulation, skin and topical therapy.

Fig.2 The possible mechanisms of liposome-cell interaction.

Liposomes can be used as a carrier for a variety of drugs, having a potential therapeutic action. Various therapeutic agents including anticancer drugs, vaccines, antimicrobials, genetic materials, proteins and macromolecules can be encapsulated within the bilayered vesicles. So far, the liposomal technology has been used for the successful encapsulation of various drug molecules, for example, paclitaxel, acyclovir, tropicamaide, arteether, chloroquine diphosphate, cyclosporine, dithranol and so on. Liposomes have the advantages of improved pharmacokinetics and biodistribution of therapeutic agents thus minimizing by-stander toxicity and improving potency by its accumulation at the target tissue. To date, there are approximately a dozen liposome-based drugs approved for clinical use with more in various stages of clinical trials.

Creative Biolabs is specialized in the targeted delivery system design and preparation that are suitable for a number of disease therapies and detections. We offer customized solutions to meet every specific research requirement of our clients. Please contact us to experience the value of our expert services.

Reference

1. Riaz, Muhammad Kashif, et al. "Surface functionalization and targeting strategies of liposomes in solid tumor therapy: A review." International journal of molecular sciences 19.1 (2018): 195.

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