Targeting Module
Targeting modules have advantages to specifically targeting diseases, organs or tissues, subcellular organelles and microorganisms. They have been widely used in targeting payload delivery system and non-invasive imaging. Creative Biolabs has over a decade of working experience in antibody and peptide design and modification to fit various bio-conjugation strategies. Based on our advanced platform, we offer a full range of targeting modules for targeted delivery services in cancer treatment and diagnosis. Our scientific team can help you with every step in the development process, from design to validation, from concept to reality.
Targeted delivery is a method of delivering medication to patient in a manner that increases the concentration of the medication in the targeted part of the body. In general, the most common medications are chemical molecules and biologics. The latter, often including the antibodies, peptides and scaffold proteins, are actively developed and evaluated in recent years.
An antibody, also referred to as an immunoglobulin (Ig), is a large Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses. The antibody recognizes a unique antigen via the Fab's variable region, which may impede the biological process causing the disease or may activate macrophages to destroy the foreign substance. The ability of an antibody to work in tandem with other components of the immune system is mediated via its Fc region. Antibodies often functionally mediate the biological processes by neutralization, agglutination, precipitation and complement activation. Therefore, antibodies have been used widely in cancer and other disease treatments.
Fig.1 Schematic representation of antibodies.
Peptides are a series of short chains of amino acid monomers linked by peptide (amide) bonds. Peptides are commonly divided into dipeptides, tripeptides, tetrapeptides and polypeptide. They are different from proteins on the basis of size, which contain only approximately 50 or fewer amino acids. Proteins consist of one or more polypeptides arranged in a biologically functional way to recognize ligands. Peptides, as pharmacological agents, have become an attractive therapeutic approach because of their advantages of flexibility compared to antibodies. Additionally, some peptide-based drugs have progressed into clinical development in oncology.
Fig.2 Current methods to enhance the half-life of peptide drugs and improve peptide drug delivery.1
Scaffold proteins serve as a type of critical regulators involving in many key signaling pathways. They are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes. They play important roles in regulating signal transduction and helping localize pathway components to specific areas of the cell, such as plasma membrane, cytoplasm, nucleus, Golgi, endosomes, and mitochondria. Scaffold proteins function in signaling pathways with at least four steps: tethering signaling components, localizing the components to specific areas of the cell, modulating signal transduction by coordinating positive and negative feedback signals, and insulating correct signaling proteins from competing proteins.
Creative Biolabs is committed to providing comprehensive scaffold protein expression and purification services. We have four main expression systems for high-quality protein production, including:
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Bacterial expression systems (E. coli / Bacillus)
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Yeast expression systems (P. pastoris / S cerevisiae)
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Baculovirus-insect cell expression systems
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Mammalian expression systems (CHO / 293)
Features of Our Module
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Good stability in the bloodstream
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High specificities and affinities
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Display low toxicity profiles
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Attaining biocompatibility and biodegradability
Creative Biolabs is equipped with outstanding facilities and experienced scientists. With great devotion to our clients, Creative Biolabs offers highly customarily tailored targeting module to fit your timeline and research budget. We would like to share our knowledge and passion in this field to promote the advances of science for a better tomorrow. Please contact us for more information and a detailed quote.
Reference
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Li, Caroline M., et al. "Novel peptide therapeutic approaches for cancer treatment." Cells 10.11 (2021): 2908.
Our services are For Research Use Only. We do not provide services to individuals.
