This product is a potent and selective factor D antagonist, it inhibits factor D with the IC50 of 96 nM. It also inhibits C1s with the IC50 of 1.6 nM.
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CAS No. | 217099-44-0 |
Formula | C₁₅H₁₄N₂O₅S₃ |
Molecular Weight | 398.48 |
SMILES | N=C(C1=CC2=CC=C(OC(C3=CC=CS3)=O)C=C2S1)N.O=S(O)(C)=O |
IC50 | IC50: 96 nM (Factor D); 1.6 nM (C1s); 326 nM (Trypsin) |
Purity | 98% |
Solubility | DMSO :>33.33 mg/mL (83.64 mM) |
Storage | Store at -4°C for short term; at -20 °C for long-term storage. |
Target | Factor D |
Introduction | The Factor D is a member of the trypsin family of peptidases. It is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. |