Complement C5-IN-1(Cat#: CTI-006)

This product is a potent C5 inhibitor, it interacts with C5 to prevent its cleavage by the C5 convertase and blocks zymosan-induced the membrane-attack complex (MAC) deposition in 50% human whole blood with an IC50 of 0.77 µM.

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

Lot Number

Summary Customer Reviews Related Products & Services Resources

Specifications
CAS No. 2365402-67-9
Formula C₂₄H₃₂N₂O₆
Molecular Weight 444.52
SMILES COC1=C(OCCCC(C)C)C=C(NC(N[C@H](C2=C(OC)C=CC=C2)C)=O)C(C(O)=O)=C1
IC50 IC50: 0.77 µm
Purity 95%
Storage Store at -4°C for short term; at -20 °C for long-term storage.
Target C5
Introduction The complement component C5 is an effective therapeutic target to discount the activation of complement and prevent functional cells lysis in certain disorders. C5 is cleaved into fragments of C5a and C5b by C5 convertase.

Customer Review

The product is easy to use, and the detailed protocol provided ensures that even complex experiments run smoothly
Excellent
In our lab, we have tested various inhibitors, and Complement C5-IN-1 stands out due to its efficacy and stability. It has effectively blocked the C5 component in our in vitro models, enabling us to better understand its role in disease progression.
This product has certainly streamlined our research processes
Excellent
Its potent inhibitory action on C5 has allowed us to delve deeper into the mechanisms of complement-mediated diseases. We have also found it to be highly effective in our animal models, leading to more insightful results.
The quality of Complement C5-IN-1 is outstanding
Excellent
It has provided us with reliable inhibition of C5 in our experiments, which is crucial for our studies on complement activation. The inhibitor's performance has been consistent, and its long shelf-life is an added bonus.
Proven to be an invaluable tool in our experiments
Excellent
Using complement C5-IN-1 has markedly improved our understanding of the complement system's role in autoimmunity. Its ability to specifically inhibit C5 has helped us to isolate the effects of this component and has led to significant findings in our research. We appreciate the high purity and stability of this product.
A reliable choice for our experiments
Excellent
The introduction of complement C5-IN-1 to our studies has been transformative. We have been able to dissect the role of C5 in pathological conditions with unprecedented accuracy. The product's high potency ensures complete inhibition, making our findings more robust.
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
Online Inquiry