Compstatin(Cat#: CTI-010)
This product is a 13-residue peptide, it inhibits C3 convertase with the IC50 of 28 nM and also inhibits the activation of classical and alternative complement pathways with the IC50 of 63 and 12 μM, respectively.
Summary
Customer Reviews
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Specifications
| Formula |
C66H99N23O17S2 |
| Molecular Weight |
1550.77 |
| Sequence |
ICVVQDWGHHRCT-NH2 (Disulfide bridge: Cys2-Cys12) |
| IC50 |
IC50: 28 nM |
| Purity |
98% |
| Solubility |
DMSO :>100 mg/mL (193.45 mM) |
| Storage |
Store at -20°C for short term; at -80 °C for long-term storage. |
| Target |
C3 convertase |
| Introduction |
Complement component 3, often simply called C3, is a protein of the immune system. C3 plays a central role in the activation of the complement system. Its activation is required for both classical and alternative complement activation pathways. |
Customer Review
Compstatin has significantly advanced our research in complement inhibition
Excellent
We used it in our studies to block complement activation and observed a remarkable reduction in inflammatory markers. The compound is highly specific and easy to work with. The results were consistent across multiple experiments, making it a reliable tool for our lab.
It's a powerful inhibitor that has become essential in our research
Excellent
Our lab has been using compstatin, primarily for in vitro studies of complement-mediated diseases. The compound's ability to inhibit C3 convertase is impressive, and we've noticed a clear decrease in C3b deposition in our assays.
Its stability and potency make it a valuable addition
Excellent
As a researcher focusing on autoimmune diseases, I found compstatin to be highly effective in our in vitro models. It consistently inhibited complement activation without affecting other pathways, which is crucial for our studies. The compound's purity and quality are top-notch, ensuring reproducible results.
The compound is easy to handle and provides consistent inhibition of complement activity
Excellent
In our lab, compstatin has been instrumental in studying the role of complement in neuroinflammation. The compound effectively inhibits complement activation, allowing us to dissect the specific contributions of this pathway.
High purity and consistent performance
Excellent
Compstatin has been a valuable tool in our studies on complement-driven inflammation. We used it in various in vitro assays and consistently observed inhibition of complement activation. The compound is easy to use and integrates well into our experimental workflows.
For Research Use Only. Not for Diagnostic or Therapeutic Applications.
