C1QC

Clear All
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-117
Isotype IgG1
Applications WB; ELISA; FC
Host Animal Rabbit
Specie Reactivity Human
Isotype IgG
Applications IHC
Host Animal Mouse
Specie Reactivity Human
Isotype IgG
Applications WB
Host Animal Goat
Specie Reactivity Human
Isotype IgG
Applications WB; IHC; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-760
Isotype IgG1 κ
Applications WB; IP; IF; IHC; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-760
Isotype IgG1 κ
Applications IP
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-760
Isotype IgG1 κ
Applications WB; IHC; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-760
Isotype IgG1 κ
Applications IF; IHC; FC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-760
Isotype IgG1 κ
Applications IF; IHC; FC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-760
Isotype IgG1 κ
Applications WB; IF; IHC; FC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-760
Isotype IgG1 κ
Applications WB; IF; IHC; FC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-760
Isotype IgG1 κ
Applications WB; IF; IHC; FC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-760
Isotype IgG1 κ
Applications WB; IF; IHC; FC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-760
Isotype IgG1 κ
Applications WB; IF; FC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-760
Isotype IgG1 κ
Applications WB; IF; FC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-12
Isotype IgG1
Applications WB; ELISA; Flow
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-13
Isotype IgG1 Kappa
Applications WB; IP; IF; IHC; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-13
Isotype IgG1 Kappa
Applications IP
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-13
Isotype IgG1 Kappa
Applications WB; IHC; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-13
Isotype IgG1 Kappa
Applications IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-13
Isotype IgG1 Kappa
Applications IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-13
Isotype IgG1 Kappa
Applications WB; IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-13
Isotype IgG1 Kappa
Applications WB; IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-13
Isotype IgG1 Kappa
Applications WB; IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-13
Isotype IgG1 Kappa
Applications WB; IF; IHC; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-13
Isotype IgG1 Kappa
Applications WB; IF; FCM
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-13
Isotype IgG1 Kappa
Applications WB; IF; FCM
Specie Reactivity Human
Sensitivity 49 pg/mL (125-8000 pg/mL)
Applications ELISA
Specie Reactivity Human
Sensitivity 2.34 ng/mL (9.38-600 ng/mL)
Applications ELISA
Specie Reactivity Mouse
Sensitivity 0.195 ng/mL (0.78-50 ng/mL)
Applications ELISA
Specie Reactivity Rat
Sensitivity 0.2 ng/mL (0.195-50 ng/mL)
Applications ELISA
Specie Reactivity Mouse
Sensitivity 0.082 ng/mL (0.156-10 ng/mL)
Applications ELISA
Clear All
Specie Reactivity Human
Type Recombinant Protein
Expression Host Wheat Germ (in vitro)
Applications WB; ELISA; PA; AP
Specie Reactivity Human
Type Recombinant Protein Antigen
Expression Host E. Coli
Applications AC
Specie Reactivity Human
Type Recombinant Protein
Expression Host Yeast
Applications WB; ELISA
Specie Reactivity Human
Type Recombinant Protein
Expression Host E.coli/Mammalian cell/Baculovirus
Applications WB; ELISA
Specie Reactivity Mouse
Type Recombinant Protein
Expression Host Yeast
Applications WB; ELISA
Specie Reactivity Mouse
Type Recombinant Protein
Expression Host E.coli/Mammalian cell/Baculovirus
Applications WB; ELISA
Specie Reactivity Rat
Type Recombinant Protein
Expression Host Yeast
Applications WB; ELISA
Specie Reactivity Rat
Type Recombinant Protein
Expression Host E.coli/Mammalian cell/Baculovirus
Applications WB; ELISA
Specie Reactivity Human
Purity >90%
Applications Blocking
Specie Reactivity Human
Species of Lysate 293T Cells
Application Western Blotting (WB)
Clear All
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-AC-GFP
Tag GFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-AC-GFP
Tag GFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-XL4
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Specie Reactivity Mouse
Type Expression Plasmid
Vector pCMV6-AC-GFP
Tag GFP
Specie Reactivity Mouse
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Mouse
Type Expression Plasmid
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Mouse
Type Expression Plasmid
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Mouse
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Mouse
Type Lentiviral Particle
Vector pLenti-C-mGFP-P2A-Puro
Tag GFP
Specie Reactivity Mouse
Type Expression Plasmid
Vector PCMV6-Kan/Neo
Specie Reactivity Rat
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Rat
Type Expression Plasmid
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Rat
Type Expression Plasmid
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Rat
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Rat
Type Lentiviral Particle
Vector pLenti-C-mGFP-P2A-Puro
Tag GFP
Specie Reactivity Rat
Type Expression Plasmid
Vector pCMV6-Entry
Product List Background

Background

Complement C1, the first member of the classical complement pathway, is a protein complex composed of the subcomponents C1q, C1r, and C1s. Among these subcomponents, C1q is a 460 kDa protein made up of 18 polypeptide chains, 6 C1QA, 6 C1QB, and 6 C1QC chains, respectively. Human complement C1q subcomponent subunit C (C1QC) is a 24 kDa polypeptide chain with 245 amino acids forming a lollipop-like structure. In the lollipop-like structure of C1QC, about 81 amino acids near the N terminus yield the collagen-like ‘rod’, and ~136 residues at the C terminal form the globular ‘head’ structure. The collagen-like region of C1QA, C1QB, and C1QC link to each other forming a triple-helical structural strand. And then C1QC of one strand is linked to the adjacent C chain by a disulfide bond forming an ABC-CBA doublet. 6 such triple helical strands or 3 ABC-CBA doublets non-covalently combine resulting in the intact complement C1q with a bouquet-like structure.

The human C1QA, C1QB, and C1QC encoded genes are arranged in the order A-C-B on chromosome 1. Abnormal expression of any C1QA, C1QB, and C1QC will lead to defective C1q function, causing the C1q to fail to bind to antigen-antibody complex and activate the classical complement pathway. Deficiency of C1QC or C1q has been associated with immunodeficiency and autoimmune diseases.

Fig. 1 Structure and assembly of C1QC subunit. (Ain et al., 2021)Fig. 1 Structure and assembly of C1QC subunit.1

Reference

  1. Ain, Danyaal, et al. "The role of complement in the tumor microenvironment." Faculty Reviews 10 (2021).
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For Research Use Only.