C1ra (complement component 1, r subcomponent A), also known as mC1rA or C1r, serves as a serine protease. C1ra is found to be expressed in various structures such as the adrenal gland, small intestine, blood, and midbrain. In addition, C1ra is also found in the lymphatic system and the genitourinary system. As an integral component of the classical complement pathway, C1ra is closely linked to innate immune regulation.
Its Gene ID: 50909 and UniProtKB ID: Q8CG16.
The C1ra gene is orthologous to human C1R (complement C1r). However, unlike humans, the mouse C1r gene duplicates into C1ra and C1rb. In mice, the C1ra zymogen spans 691 amino acids (aa) and contains a CUB domain, an EGF-like motif, a second CUB domain, two CCP repeats, and a C-terminal peptidase S1 region. The data show that for AA 17-707, mouse C1ra is 91% identical to rat and 82% identical to human C1r. The aa sequence identity between full-length mouse C1ra and mouse C1rB is 96%.
This component, encoded by the C1ra gene, works synergistically with C1rb to bind immune complexes or microbial pathogens. Completion of binding triggers a signal leading to activation of the C1 complex. In addition to facilitating the initiation of immune responses, activation of the classical complement pathway can also promote opsonization, inflammation, as well as pathogen clearance. Characterizing the function of complement C1ra in mice allows for a better understanding of the mechanisms by which the immune system recognizes and eliminates foreign invaders, which provides new horizons for the treatment of immune diseases.
Fig.1 Expression of inflammation-related genes in isolated microglia during experimental autoimmune encephalomyelitis.1
Mouse C1ra ELISA kits are suitable for in vitro quantitative measurement of C1ra in a variety of samples, including plasma, cell lysates, and cell culture supernatants.
Our diverse antibodies are validated to be highly specific for mouse C1ra. Our C1ra antibodies are primarily derived from sheep and rats.
Our cost-effective C1ra protein products are suitable for a variety of applications such as enzyme activity assays, WB, and ELISA.
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