C1SB

Background

Creative Biolabs provides a wide range of high-quality antibodies, assay kits, and C1sb proteins to help researchers improve their experiments and research in the field of complement. Our dedication to quality ensures reliable results, enhancing the accuracy and efficiency of your experiments.

Introduction

C1sb is a group of C1s genes in mice, and another group is called C1sa, which are duplicated. C1sb, unlike C1sa, is found explicitly in the male reproductive tissues, particularly in the coagulating gland and the prostate. The murine C1sb gene is homologous to the human C1s gene. C1s is one of the subunits of C1, an intrinsic component of the classical complement activation pathway, and it is related to many autoimmune and infectious diseases. The differences between C1sb and their liver isoforms are in the amino acid sequences. The different regions correspond to surface loops surrounding the active site of the human SPs.

Complement System and C1s

The complement is a collection of active enzyme proteins found in the serum and tissue fluids of both normal humans and animals upon activation. Innate immunity relies on it heavily, and it complements the responses triggered by antibodies. Activation of the complement pathway can be initiated by antigen-antibody complexes or microorganisms, ultimately resulting in the destruction or engulfment of harmful organisms.

Fig.1 Structure of C1s.Distributed under CC BY-SA 3.0, from Wiki, without modification.

Complement component 1 is an inherent part of the classical activation pathway of complement and is made up of three subunits: C1q, C1r, and C1s. These subunits come together to form a pentameric macromolecular complex in the presence of calcium ions in a 1:2:2 ratio (C1qC1r2C1s2). C1q binds to other activators through its collagen-like region, while C1s is a serine proteasomal proteinogen that becomes activated to act on substrates C4 and C2.

Creative Biolabs provides a wide range of high-quality antibodies, assay kits, and C1sb proteins to help researchers improve their experiments and research in the field of complement. We try our best to help you improve your experiments and accelerate the R&D process.

C1sb Functional Service

Creative Biolabs provides a comprehensive range of C1sb related products, including anti-C1sb ELISA kits, C1sb proteins, and vectors. These products can effectively carry out C1sb related experiments and thus play an important role in your research.

Fig. 2 HMGB1 is cleavable by C1s.¹

Further mass spectrometric analysis of apoptotic cell proteins processed by the C1 complex revealed additional substrates for the C1s protease. This analysis highlighted the complementary role of C1s in the clearance of apoptotic cells by proteolytically cleaving intracellular alarmins and self-antigens.¹ Besides functioning as the lytic arm of antibodies to activate the complement cascade, the C1 complex may have evolved as a mechanism for tissue renewal. This process helps to reduce the immunogenicity of apoptotic tissue fragments and minimizes the potential for autoimmunity. The C1 protease, or C1s, can cleave various intracellular proteins released during apoptosis, significantly lowering the immunogenicity of these cell fragments.

Creative Biolabs offers C1sb functional services, including C1sb binding and other tailored functional services for our esteemed clients engaged in clinical and scientific research.