Creative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsCreative Biolabs is offering the most comprehensive services for antibody development projects. With strict regulation and effective execution, we are dedicated to providing the most valuable solutions to complete your projects.
HighlightsWith over a decade of experience in phage display technology, Creative Biolabs can provide a series of antibody or peptide libraries that are available for licensing or direct screening. These ready-to-use libraries are invaluable resources for isolating target-specific binders for various research, diagnostic or therapeutic applications.
HighlightsCreative Biolabs has established a broad range of platforms for developing novel antibodies or equivalents. These cutting-edge technologies enable our scientists to meet your demands from different aspects and tailor the most appropriate solution that contributes to the success of your projects.
HighlightsWith deep understanding in antibody-related realms and extensive project experience, Creative Biolabs offers a variety of references to help you learn more about our capacities and achievements, including infographic, flyer, case study, peer-reviewed publications, and all kinds of knowledge that can assist your projects. You are also welcome to contact us directly for more specific solutions.
HighlightsGet a real taste of Creative Biolabs, one of the most professional custom service providers in the world. We are committed to providing highly customized comprehensive solutions with the best quality to advance your projects.
HighlightsTaste receptors are receptors that facilitate the detection of taste. Five taste qualities are known to be perceived by humans and many nonhuman mammals: sweet, umami, bitter, salty, and sour. Each of the qualities has a specific coding mechanism mediated by specialized taste receptors. By now, receptors for bitter, sweet, umami, and salty taste have been discovered. Sweet and umami tastants in humans are sensed by type 1 taste receptors (TAS1Rs), which belong to class C G protein-coupled receptors and comprise a family of three receptors: TAS1R1, TAS1R2, and TAS1R3. Type 2 taste receptors (TAS2Rs) belong to class A G-protein-coupled receptors and are responsible for bitter taste. There are 43 human TAS2Rs genes and thus there is a long list of TAS2R members. TAS1Rs and TAS2Rs are expressed in type II taste bud cells. However, expression of T1R and T2R receptors extends far beyond the tongue to organs as diverse as the brain, gut, pancreas, bladder, and testes; these have been termed “extraoral” taste receptors.
After activation of these receptors, their second messenger pathways lead to depolarization and intracellular calcium increase in taste receptor cells. Then, the transmitter is released from taste receptor cells leading to activation of taste nerve fibers and taste information is sent to the central nervous system. Here, we give an introduction of part of these human taste receptor members focusing on structure, function, signaling, polymorphism, and therapeutic potential.
| Human Taste Receptor Members | ||||
| TAS1R1 | TAS1R2 | TAS1R3 | TAS2R1 | TAS2R5 |
| TAS2R7 | TAS2R8 | TAS2R9 | TAS2R10 | TAS2R14 |
| TAS2R16 | TAS2R38 | TAS2R43 | TAS2R45 | TAS2R46 |
| TAS2R50 | TAS2R60 | |||
Taste receptors represent attracting pharmaceutical targets for different human diseases, making their production vitally important. Aided by our cutting-edge Magic™ membrane protein production platform, Creative Biolabs offers efficient expression and solubilization services of these protein targets using a variety of detergents, membrane mimetics, and lipids to yield structurally and functionally intact membrane proteins for in vitro studies. We can prepare your protein of interest in systems such as detergent micelles, proteoliposomes, nanodiscs, lipoparticles, and polymers.
Meanwhile, we introduce our Magic™ membrane protein antibody discovery platform that enables the discovery of highly functional antibodies against these targets to help promote your studies. We also present DNA immunization service for anti-membrane protein antibody development. Please feel free to contact us for more information.
All listed services and products are For Research Use Only. Do Not use in any diagnostic or therapeutic applications.
