Cantagalo Virus Vaccine

Creative Biolabs is a specialized vaccine research and development company based on the international stage. Since its establishment more than ten years ago, the company has been focusing on the vaccine field, continuously expanding its research and development team, perfecting the research and development system, and now has rich R&D experience and mature supporting services. We can meet all the needs of customers in vaccine development.

Cantagalo Virus

Cantagalo virus, a new potential established vaccinia virus, is isolated from an outbreak of pox-like disease that took place in Cantagalo, a country in the state of Rio de Janeiro, Brazil. During the episodes, the disease was prevalent in several farms and affected milkers and dairy cattle there. The disease caused by Cantagalo virus has clinical symptoms similar to those of cowpox, for example, papules on the udders and teats of the infected cows, which were developed from vesicle to pustules. The disease is usually healed within three weeks but leaves scars on animals. Milkers and their families subsequently infected the virus from those sick cows and present lesions on their hands and arms. And the infection is often accompanied by malaise, fever, and axillary lymphadenopathy. Sometimes generalized vesicular lesions are developed on the bodies of patients in some conditions. Cantagalo virus is similar to other poxvirus in morphology with brick-shaped virion whose core is enveloped by outer membrane and is biconcave. The virus also replicates in the cytoplasm of the host.

Immunology of Cantagalo Virus Infection

The mammalian immune system is able to use a variety of cytokines to protect the body against infection by various pathogens. IL4 produced by Th2 lymphocytes can promote antibody production and affect T cell-mediated immune responses by interfering with the formation of cytotoxic T cells and the production of IFN-γ. CTL cells and IFN-γ are the key factors for the body to clear pathogens during viral infection. An engineered mousepox virus that was inserted an IL4-encoding gene could cause severe disease or high mortality in mouse that are genetically resistant to the ectromelia virus, an alternative name of mousepox virus. This study shows that IL4-bearing poxvirus has a potential as a super-pathogen and pose a threat for humans who are likely to be attacked by such engineered virus. Some researches also show that Orthopoxviruses consisting of genes that encode certain proteins which bind to IL18 are more virulent than those do not have such genes. Besides, scientists found that IL17 and IL23 are also of significant importance to resist the virus.

Tumor necrosis factor, also known as TNF, is crucial in protecting body against bad outcomes that raised by viral infection. Virus from genus Orthopoxviruses targets TNF as a strategy to interfere with anti-viral immune responses in host and escape from clearance of the immune system.

The Development of the Cantagalo Virus Vaccine

Diseases that caused by Cantagalo virus are usually mild and self-healing. At present, most vaccines against Cantagalo virus are prepared based on vaccinia virus. Creative Biolabs is an expert in the development of poxvirus vaccines. The company has more than 10 years of experience in the development of poxvirus vaccines. We have a team of professional scientists and have successfully established a well-developed and comprehensive research and development platform. Vaccines of various members of the poxvirus family have been studied and successfully prepared by us. We are able to design and prepare different types of vaccines (attenuated/inactivated/recombinant subunits, etc.) according to the different needs of our customers, and can provide specific services related to vaccines, such as antigen synthesis and codon optimization, the construction of candidate vaccines, the establishment of animal models, immunological evaluation of candidate vaccines, vaccine formulation design and production process optimization and other comprehensive services.

All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.