Cowpox Virus Vaccine
Creative Biolabs, a company specializing in vaccines, has accumulated considerable success in decades of research and development. We have done a lot of research in the field of poxvirus vaccines. We have a team of experienced scientists, a well-developed and mature research and development system, which can provide you with all the best quality services for cowpox vaccine development.
Cowpox Virus
Cowpox is a contagious disease caused by the cowpox virus, which belongs to the family Poxviridae and is the most closely related virus to vaccinia and can spread between humans and animals. Cowpox is more common in rodents than in bovines. Cowpox virus is similar to variola virus but is relatively milder and less toxic. It was observed that the dairy farmers infected with the cowpox virus was able to immune from the variola virus and thus inspired Edward Jenner to invent the first smallpox vaccine. Nowadays, it is not cowpox virus but vaccinia virus that is being used to prevent smallpox, however, the effectiveness of two vaccines are almost the same. The virus is distributed mainly in the UK and there are few human cases are reported, in which the infected people usually get the virus from cats. It is also rarely found in cattle while woodland rodents such as voles are the reservoir of the virus. Domestic cats those infected the cowpox virus transmit the virus to humans later. Human infection with cowpox virus usually manifests as local symptoms, and the symptoms are lighter and self-healing, but infection with the virus by immunosuppressed people may lead to death.
The Development of the Cowpox Vaccine
Cowpox virus is more harmful than zoonotic pathogens such as buffalopox virus. There have been reports of human, monkey and zoo elephants dying from this virus. Once the elephant was infected with cowpox virus, it had to be euthanized to relieve its pain, causing a huge loss of precious animal resources. Currently, VACV-MVA strain is approved for inoculation of zoo animals in Europe and is protective in rabbits, elephant, and rhinoceros. Another inactivated vaccine also provides desirable immunity in rabbits model, indicating a promising vaccine candidate against cowpox. Lately, a replicon particles of Venezuelan equine encephalitis virus is being studied for preventing infections by poxvirus, the recombinant VRP (replicon particles of Venezuelan equine encephalitis virus) expressing A27, A33 and B5 proteins of CPXV could stimulate immunized mice to produce IgG1 and IgG2a and the immune response could last for at least 50 weeks. In addition, the subunit vaccines of protein A27, A33 or B5 are also protective in mice whether administrated separately or in combination. So up to now, VACV-based attenuated or inactivated vaccines, VRP-based recombinant and subunit protein vaccine candidates are main strategies for cowpox vaccine. Creative Biolabs tracks the world's latest progress in vaccine development and leads a team of professionals to continuously innovate vaccine development strategies and methods and improve existing technologies and platforms. Today, it has become a leader in the field of poxvirus vaccines. We have intensive and extensive research on cowpox virus vaccine, hence can design and prepare vaccines with good immunogenicity. We can also provide safety and efficacy evaluation of vaccine candidates, follow-up formula design (adjuvant selection etc.), and a series of services such as mass production and process optimization.
Services
- Design of vaccine candidate
- Construction of customized animal model
- Related immunogenicity testing
- Toxicology and histopathology study
- Formulation design and optimization
Decades of professional research in the field of vaccines have enabled today's Creative Biolabs. With in-depth research in the field of poxvirus vaccines, the company has established a comprehensive R&D platform with high-quality staff to handle all challenges in developing vaccines flexibly and efficiently. We will escort you along the path for the development of the cowpox vaccine.
All of our products can only be used for research purposes. These vaccine ingredients CANNOT be used directly on humans or animals.
