Site-Specific Conjugation Platform
What is Site-specific Conjugation?
Conventional conjugation methods generate a variety of heterogeneous. Site-specific conjugation overcomes this disadvantage by linking molecules based on specific sites. We are dedicated to delivering tailored conjugation services that cater to your diverse research requirements.
Fig. 1 The application of the site-specific conjugation methods.
Multiple Conjugation Methods
Amino Acids Sites
We can provide two conjugate services that depend on amino acid sites for greater homogeneity. The first is based on natural or engineered modifications of specific amino acids, such as cysteine and glutamine; the other is based on the insertion of amino acids, including selenocysteine, and the unnatural amino acid, etc.
Glycans
This approach employs a glycotransferases to achieve conjugation at sites far from amino acid residues. Based on this technology, we can selectively transfer chemically reactive sugar to any lipid or protein that contains glycosylation sites.
There are several monosaccharides present at the non-reactive end of the glycans that we can use for conjugating, including fucose (Fuc), galactose, sialic acid (SA), etc.
Short Peptide Tags
We can add short peptide tags with 4-6 amino acid residues to provide you with conjugate services, such as glutamine tags (LLQG).
Our Custom Bioconjugation Services
Linker Development
We have an extensive linker library and can also customize linkers to suit your needs.
Biomolecules
| Protein & Antibody | Oligonucleotide |
| Nucleic Acids/Oligonucleotides | Oligosaccharide |
| Small Molecule | Liposome |
| Bacteria | Bead & Particle |
| Virus | Metal Chelates |
| Bacteriophage | PEG |
| Fluorescent | Photoaffinity Label |
Custom Bioconjugation
We have extensive experience in bioconjugation, including these biomolecules on the right.
Ligand Screening
With ligand screening through bioconjugate technology, we can help you with your drug discovery.
Application
Based on conjugating, we can meet your diverse research needs, including Discovery of Biological Interactions, Biochemical Assays, Drug Delivery, Imaging In Vivo, PEGylation and Industrial.
Creative Biolabs holds a prominent position in the field of bioconjugate, with our experts' possessing years of experience in conjugation. Based on our unique Site-specific Conjugation Platform, we offer comprehensive custom services to assist your project throughout the entire process, from preclinical research to commercial-scale production. Should you express interest in our services, please feel free to contact us for comprehensive information.
References
- Zhou Q. Site-Specific Antibody Conjugation for ADC and Beyond. Biomedicines. 2017, 5(4): 64.
- Panowski S.; et al. Site-specific antibody drug conjugates for cancer therapy. MAbs. 2014, 6(1): 34-35.