C3c

Background

Creative Biolabs provides a wide range of high-quality antibodies, assay kits, and C3c proteins to help researchers improve their experiments and research in the field of complement. Our dedication to quality ensures reliable results, empowering researchers to produce publication-grade data.

Introduction

Complement is a group of enzymatically active proteins present in average human and animal serum and tissue fluids upon activation. It is an essential component of intrinsic immunity and a complement to antibody-triggered responses; hence, it is called a complement. Antigen-antibody complexes or microorganisms can activate the complement pathway, ultimately leading to the lysis or phagocytosis of pathogenic organisms.

Fig.1 Structure of Complement C3.Distributed under CC BY-SA 3.0, from Wiki, without modification.

Complement C3 is a joint complement component, which is mainly synthesized by macrophages and the liver and has the highest content in serum. It is the most abundant complement component. In the classical complement activation pathways, the C3 converting enzyme cleaves C3 into two fragments, C3a and C3b. Clinically, the diseases that can cause the increase of complement C3 are mainly infectious, tissue damage, and other diseases, such as arthritis and liver cancer. Some diseases can cause low complement C3, including nephritis, systemic lupus erythematosus, hepatitis, cirrhosis, etc.

Biomarker in Heart Failure

Heart failure (HF) is a disease caused by the heart's inability to pump blood properly, resulting in the heart being unable to meet the body's basic metabolic needs. Heart failure patients often have lower levels of immune system activation. After cardiac injury, activation of the innate immune system is critical for adequate healing. Activation of the innate immune system plays a vital role in the healing of acute cardiac injury, and the complement system is crucial in immune activation.

All activation steps converge on complement C3. In the heart, activated C3 can lead to tachycardia, atrioventricular conduction disturbances, left ventricular systolic failure, and coronary vasoconstriction. This shows that C3 correlates with the inflammatory response in the cardiovascular system, making it possible to use it as a biomarker. In addition, as a conversion product of C3, C3c is more stable compared to C3, making it suitable as a biomarker for heart failure patients.

Creative Biolabs provides various antibodies, assay kits, and proteins for C3c, satisfying your research demands. We are dedicated to helping you improve your experiments and accelerate the R&D process in the field of neuroscience.

C3c Functional Service

Creative Biolabs offers an extensive array of products aimed at C3c functionality, encompassing antibodies tailored to C3c, ELISA kits for detecting C3c, and recombinant C3c proteins. These meticulously developed reagents are vital for elucidating the interactions between C3c proteins and various molecular entities, thereby advancing research focused on developing therapeutic strategies for a wide range of diseases.

Fig.2 Comparison of initial salivary C3 and C3c concentrations between periodontitis patients and individuals with periodontal health.¹

Researchers have explored the role of the complement system in the inflammatory responses leading to tissue destruction in periodontal disease. This study aimed to compare salivary concentrations of C3 and its derivative C3c in individuals with periodontitis versus healthy controls, and to assess their utility as biomarkers for diagnosing and monitoring the disease. Salivary tests, analyzing stimulated saliva samples from both patient groups using sandwich ELISA, revealed significantly elevated baseline levels of C3 and C3c in periodontitis patients. These levels effectively distinguished periodontitis severity and predicted treatment response, with lower C3c levels linked to a better clinical outcome. Thus, salivary C3c emerges as a promising biomarker for evaluating non-surgical periodontal treatment responses.

Creative Biolabs offers an extensive array of services focused on C3c functionality, comprising C3c-binding assays and tailored functional evaluations. These services are thoughtfully designed to support esteemed clients in advancing their clinical and research initiatives.

Reference

1. Grande, Maria Anastasia, et al. "Complement split product C3c in saliva as biomarker for periodontitis and response to periodontal treatment." Journal of Periodontal Research 56.1 (2021): 27-33. Distributed under Open Access license CC BY 4.0, without modification.