Terminal complement complex (TCC), also known as the membrane attack complex (MAC), is a protein complex formed on the surface of the pathogen cell membrane due to the activation of the host complement system. In general, the terminal components include C5b, C6, C7, C8, and several C9 molecules. Assembly of the terminal components would result in disruption of the cell membrane of the target cell, leading to cell lysis and death. Here, Creative Biolabs briefly summarizes the hemolytic assay protocol for terminal components to promote your research. Creative Biolabs briefly summarizes the hemolytic assay protocol for terminal components to promote your research.
Hemolytic Assay Protocol for Terminal Components
Fig.1 Flow chart of the hemolytic assay protocol for terminal components. (Creative Biolabs)
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Published Data
Fig 2. Relationship between terminal complement complex formation and intervertebral disc degeneration.1
The relationship between the terminal complement complex (TCC) and intervertebral disc degeneration (DD) was examined in this study. The deposition and effects of TCC and its inhibitor CD59 in different regions of the disc tissue of DD patients, including the annulus fibrosus (AF), nucleus pulposus (NP), and endplate (EP) were investigated. The findings revealed a positive correlation between TCC deposition in the NP and EP regions and the progression of disc degeneration, based on tissue biopsies collected from various donors. Additionally, patients with adolescent idiopathic scoliosis (AIS) exhibited a lower percentage of TCC-positive cells in different tissues. This observation suggests that TCC deposition has limited effects on cells in non-degenerative discs.
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Reference
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Wu, Meng, Bei-bei Jia, and Mo-fei Li. "Complement C3 and activated fragment C3a are involved in complement activation and anti-bacterial immunity." Frontiers in Immunology 13 (2022): 813173. Distributed under Open Access license CC BY 4.0, without modification.
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