C1QA

Clear All
Host Animal Mouse
Specie Reactivity Human; Mouse; Rat
Antibody Clone CTJS-50
Isotype IgG2b
Applications WB; FC; IA; IF; IHC; Funcs
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-488
Isotype IgG1
Applications WB; ELISA; FC; IF; IHC
Host Animal Rat
Specie Reactivity Human
Antibody Clone CTJS-88
Isotype IgG2b
Applications WB
Host Animal Rat
Specie Reactivity Mouse
Antibody Clone CTJS-121
Isotype IgG1
Applications ChIP; IA; IF; IHC
Host Animal Mouse
Specie Reactivity Human
Isotype IgG
Applications WB
Host Animal Chicken
Specie Reactivity Human
Isotype IgY
Applications WB; ELISA; IF; IHC
Host Animal Rabbit
Specie Reactivity Human
Isotype IgG
Applications IF
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-440
Isotype IgG2b
Applications WB; ELISA; IHC; FC; ICC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-687
Isotype IgG2a
Applications WB; ELISA; IHC; FC;ICC
Host Animal Rabbit
Specie Reactivity Rat; Human
Antibody Clone CTJS-374
Isotype IgG
Applications WB; IHC
Host Animal Rabbit
Specie Reactivity Human
Antibody Clone CTJS-119
Isotype IgG
Applications WB; FC; IHC
Host Animal Rabbit
Specie Reactivity Human
Antibody Clone CTJS-493
Isotype IgG
Applications WB
Host Animal Rat
Specie Reactivity Mouse
Antibody Clone TJL-08
Isotype IgG1
Applications IF; IHC(P); FCM
Host Animal Rat
Specie Reactivity Mouse
Antibody Clone TJL-08
Isotype IgG1
Applications IF; IHC(P); FCM
Host Animal Mouse
Specie Reactivity Mouse
Antibody Clone TJL-09
Isotype IgG2b
Applications WB; ICC/IF; IHC; IHC-Fr
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-10
Isotype IgG2b Kappa
Applications WB; IHC(F); IHC(P)
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-10
Isotype IgG2b Kappa
Applications WB; IHC; IHC-P
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-10
Isotype IgG2b Kappa
Applications WB; IHC; IHC-P
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-10
Isotype IgG2b Kappa
Applications WB; IHC; IHC-P
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-10
Isotype IgG2b Kappa
Applications WB; IHC; IHC-P
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-10
Isotype IgG2b Kappa
Applications WB; IHC; IHC-P
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-10
Isotype IgG2b Kappa
Applications WB; IHC; IHC-P
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-10
Isotype IgG2b Kappa
Applications WB; IHC; IHC-P
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-10
Isotype IgG2b Kappa
Applications WB; IHC; IHC-P
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-10
Isotype IgG2b Kappa
Applications WB; IHC; IHC-P
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-10
Isotype IgG2b Kappa
Applications WB; IHC; IHC-P
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-10
Isotype IgG2b Kappa
Applications WB; IHC; IHC-P
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-10
Isotype IgG2b Kappa
Applications WB; IHC; IHC-P
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-10
Isotype IgG2b Kappa
Applications WB; IHC; IHC-P
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-10
Isotype IgG2b Kappa
Applications WB; IHC; IHC-P
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-10
Isotype IgG2b Kappa
Applications WB; IHC; IHC-P
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-10
Isotype IgG2b Kappa
Applications WB; IHC; IHC-P
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-10
Isotype IgG2b Kappa
Applications WB; IHC; IHC-P
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-10
Isotype IgG2b Kappa
Applications IHC; IHC-P
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-10
Isotype IgG2b Kappa
Applications WB; IHC; IHC-P
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-10
Isotype IgG2b Kappa
Applications WB; IHC; IHC-P
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-10
Isotype IgG2b Kappa
Applications WB; IHC; IHC-P
Clear All
Specie Reactivity Human
Sensitivity 35 pg/mL (78-5000 pg/mL)
Applications ELISA
Specie Reactivity Human
Sensitivity 2.34 ng/mL (9.38-600 ng/mL)
Applications ELISA
Specie Reactivity Mouse
Sensitivity 0.065 ng/mL (0.156-10 ng/mL)
Applications ELISA
Specie Reactivity Mouse
Sensitivity 15.6 pg/mL (15.6-1000 pg/mL)
Applications ELISA
Specie Reactivity Rat
Sensitivity 0.67 ng/mL (1.56-100 ng/mL)
Applications ELISA
Specie Reactivity Rat
Sensitivity 0.16 ng/mL (0.156-40 ng/mL)
Applications ELISA
Specie Reactivity Porcine
Sensitivity 0.027 µg/mL (0.027-20 µg/mL)
Applications ELISA
Specie Reactivity Bovine
Sensitivity 1.56 ng/mL (1.56-100 ng/mL)
Applications ELISA
Specie Reactivity Human
Type Recombinant Protein
Expression Host Wheat Germ (in vitro)
Applications WB; ELISA; PA; AP
Specie Reactivity Human
Type Recombinant Protein
Expression Host E. Coli
Applications WB; ELISA; PA
Specie Reactivity Human
Type Recombinant Protein
Expression Host E.coli
Applications WB; ELISA; IP
Specie Reactivity Mouse
Type Recombinant Protein
Expression Host E.coli
Applications WB; ELISA; IP
Specie Reactivity Rat
Type Recombinant Protein
Expression Host E.coli
Applications WB; ELISA; IP
Specie Reactivity Human
Purity >90%
Applications Blocking; IHC; WB
Specie Reactivity Human
Purity >90%
Applications Blocking
Specie Reactivity Human
Species of Lysate 293T Cells
Application Western Blotting (WB)
Clear All
Specie Reactivity Human
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-Myc-DDK
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-mGFP
Tag mGFP
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Human
Type Expression Plasmid
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK
Tag Myc-DDK
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-mGFP
Tag mGFP
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Human
Type Lentiviral Particle
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Mouse
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Mouse
Type Expression Plasmid
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Mouse
Type Expression Plasmid
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Mouse
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Mouse
Type Lentiviral Particle
Vector pLenti-C-mGFP-P2A-Puro
Tag GFP
Specie Reactivity Mouse
Type Expression Plasmid
Vector pCMV6-AC-GFP
Tag GFP
Specie Reactivity Mouse
Type Expression Plasmid
Vector PCMV6-Kan/Neo
Specie Reactivity Rat
Type Expression Plasmid
Vector pCMV6-Entry
Tag Myc-DDK
Specie Reactivity Rat
Type Expression Plasmid
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Rat
Type Expression Plasmid
Vector pLenti-C-mGFP-P2A-Puro
Tag mGFP
Specie Reactivity Rat
Type Lentiviral Particle
Vector pLenti-C-Myc-DDK-P2A-Puro
Tag Myc-DDK
Specie Reactivity Rat
Type Lentiviral Particle
Vector pLenti-C-mGFP-P2A-Puro
Tag GFP
Specie Reactivity Rat
Type Expression Plasmid
Vector pCMV6-Entry
Product List Background

Background

Complement C1q subcomponent subunit A (C1QA) is a constituent of the complement component C1q (a subunit of the first complement component C1). Human C1QA is a 28 kDa polypeptide chain with 244 amino acids forming a lollipop-shaped structure, of which 81 amino acids form a long collagen-like N-terminal "stalk" and 136 amino acids form a characteristic spherical "head". C1QA polypeptide chain is connected to C1QB chain by disulfide bond forming an A-B or B-A doublet, whereas, C1QC is connected to adjacent C chain by a disulfide bond forming a C-C doublet. These disulfide-linked doublets are noncovalently linked to form a ‘bouquet-of-flowers’ like hexamer structure, that is intact complement component C1q.

C1QA functions as a sub-chain of complement C1q, which together with C1q form the complement C1 complex. When antigen-antibody complexes are formed, the 6 triple helical strands of C1q can bind to the Fc domains of antibodies, such as IgM and IgG (except IgG4), leading to the activation of the complement classical pathway. C1QA abnormality causes C1q deficiency, complement dysfunction, and immunodeficiency.

Fig. 1 Structure and assembly of C1q subunit. (Ain et al., 2021) Fig. 1 Structure and assembly of C1q subunit.1

Reference

  1. Ain, Danyaal, et al. "The role of complement in the tumor microenvironment." Faculty Reviews 10 (2021).
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For Research Use Only.