C3A

Clear All
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-143
Isotype IgG1κ
Applications ELISA; WB
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-143
Isotype IgG1κ
Applications ELISA; IHC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-562
Isotype IgG1κ
Applications FC; IHC; Neut
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-448
Isotype IgG1κ
Applications WB; ELISA; IF; IHC
Host Animal Rabbit
Specie Reactivity Human; Mouse
Antibody Clone CTJS-702
Isotype IgG
Applications WB; FC; IF; IHC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-337
Isotype IgG1
Applications WB; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-241
Isotype IgG1
Applications WB; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-643
Isotype IgG1
Applications WB; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-189
Isotype IgG2b
Applications WB
Host Animal Goat
Specie Reactivity Human
Isotype IgG
Applications WB; ICC; ELISA
Host Animal Mouse
Specie Reactivity Porcine
Antibody Clone CTJS-90
Isotype IgG2b, κ
Applications WB; ELISA; IP; FuncS
Host Animal Mouse
Specie Reactivity Porcine
Antibody Clone CTJS-636
Isotype IgG1, κ
Applications WB; ELISA; FuncS
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-143
Isotype IgG1, κ
Applications WB; ELISA
Host Animal Rabbits
Isotype IgG
Applications Western Blots; ELISA; Immunodiffusion
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-37
Isotype IgG1
Applications IHC(P); ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-38
Isotype IgG1
Applications WB; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-39
Isotype IgG1
Applications WB; ELISA
Host Animal Rat
Specie Reactivity Mouse
Antibody Clone TJL-40
Isotype IgG2a
Applications Flow
Clear All
Specie Reactivity Human
Sensitivity 7.81 ng/mL (31.25-2000 ng/mL)
Applications ELISA
Specie Reactivity Human
Sensitivity 0.37 pg/mL (0.78-50 pg/mL)
Applications ELISA
Specie Reactivity Human
Sensitivity 0.120 ng/mL (0.313-20 ng/mL)
Applications ELISA
Specie Reactivity Mouse
Sensitivity 0.039 ng/mL (0.156-10 ng/mL)
Applications ELISA
Specie Reactivity Mouse
Sensitivity 6.1 pg/mL (15.6-1000 pg/mL)
Applications ELISA
Specie Reactivity Rat
Sensitivity 2.76 pg/mL (6.25-400 pg/mL)
Applications ELISA
Specie Reactivity Rat
Sensitivity 0.39 ng/mL (1.56-100 ng/mL)
Applications ELISA
Specie Reactivity Rabbit
Sensitivity 1.56 ng/mL (6.25-400 ng/mL)
Applications ELISA
Specie Reactivity Porcine
Sensitivity 3.5 pg/mL (7.8-500 pg/mL)
Applications ELISA
Specie Reactivity Dog
Sensitivity 3.13 ng/mL (3.13-200 ng/mL)
Applications ELISA
Specie Reactivity Monkey
Sensitivity 0.094 ng/mL (0.156-10 ng/mL)
Applications ELISA
Specie Reactivity Human
Sensitivity 0.007 ng/mL (0.008-5.0 ng/mL)
Applications ELISA
Specie Reactivity Human
Sensitivity 0.120 ng/mL (0.313-20 ng/mL)
Applications ELISA
Specie Reactivity Human
Type Recombinant Protein
Expression Host E. Coli
Applications Bioactivity Assays
Specie Reactivity Mouse
Type Recombinant Protein
Expression Host E. Coli
Applications Bioactivity Assays
Specie Reactivity Human
Type Native Protein
Applications Functional Assays; ELISA; RIA
[Cat#: CTI-007] C3a 70-77
CAS No. 63555-63-5
Solubility Soluble in DMSO
Product Overview This product is an octapeptide corresponding to the COOH terminus of C3a, it displays the specificity and 1 to 2% biologic activities of C3a.
[Cat#: CTI-008] C3a (70-77) TFA
Solubility Soluble in DMSO
Product Overview This product is an octapeptide corresponding to the COOH terminus of C3a, it displays the specificity and 1 to 2% biologic activities of C3a.
Product List Background

Background

Complement C3a, a small 9 kDa peptide, has 77 amino acids and made up of four anti-parallel helical structures that are trapped by three disulfide bridges. C3a is an important chemotactic mediator in the immune system, and the C3a/C3aR pathway plays crucial anti-inflammatory and proinflammatory roles in different cells and diseases. Generally, C3a/C3aR participates in the response of the immune system in three ways, including (1) activate dendritic cells (DCs), acting on resident innate immune cells to up-regulate or down-regulate different cytokines, and regulate T cell signaling between lymphocytes and antigen presenting cells (APCs).

Double edged sword of C3a/C3aR. Fig. 1 Double edged sword of C3a/C3aR.1, 2

Besides, C3a also has anti-inflammatory effects in pathogens, such as neutrophils in the bone marrow reservoir, bacteria/fungi, as well as natural killer (NK) cells. What’s more, although there is a high expression of functional C3aR on the neutrophil cell membrane, C3a does not stimulate neutrophil degranulation to activate inflammatory response. Also, through directly inhibiting neutrophil mobilizing factors (e.g., G-CSF), C3a can suppress the migration of neutrophils from the bone marrow into the circulation. Typically, in healthy individuals, the plasma concentration of C3a is 119 ng/mL, and it is generated by the degradation of C3 in the alternative pathway. But in different researches, owning to protocol and sample characteristics, the C3a concentration varies widely, from 20 to 156 ng/mL.

References

  1. Gao, Shuang, Zhao Cui, and Ming-hui Zhao. "The complement C3a and C3a receptor pathway in kidney diseases." Frontiers in immunology 11 (2020): 1875.
  2. under Open Access license CC BY 4.0, without modification
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For Research Use Only.