C3aR

Clear All
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-814
Isotype IgGκ
Applications ELISA; FC; IF
Host Animal Rabbit
Specie Reactivity Human
Antibody Clone CTJS-814
Isotype IgGκ
Applications ELISA; IF; FC;
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-875
Isotype IgG2a
Applications FC;
Host Animal Mouse
Specie Reactivity Rat
Antibody Clone CTJS-779
Isotype IgG1
Applications FC; IHC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-13
Isotype IgG2b
Applications FC; IHC
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-869
Isotype IgG1
Applications FC; IHC
Host Animal Rabbit
Specie Reactivity Human; Mouse
Isotype IgG
Applications WB; IB; IHC
Host Animal Mouse
Specie Reactivity Rat
Antibody Clone CTJS-779
Isotype IgG1
Applications FC
Host Animal Mouse
Specie Reactivity Rat
Antibody Clone CTJS-779
Isotype IgG1
Applications FC; IHC
Host Animal Mouse
Specie Reactivity Rat
Antibody Clone CTJS-779
Isotype IgG1
Applications FC; IHC
Host Animal Mouse
Specie Reactivity Human; Mouse; Rat
Antibody Clone CTJS-55
Isotype IgG2a κ
Applications WB; IP; IF; ELISA
Host Animal Mouse
Specie Reactivity Human; Mouse; Rat
Antibody Clone CTJS-55
Isotype IgG2a κ
Applications IP
Host Animal Mouse
Specie Reactivity Human; Mouse; Rat
Antibody Clone CTJS-55
Isotype IgG2a κ
Applications WB; IHC; ELISA
Host Animal Mouse
Specie Reactivity Human; Mouse; Rat
Antibody Clone CTJS-55
Isotype IgG2a κ
Applications IF; IHC; FC
Host Animal Mouse
Specie Reactivity Human; Mouse; Rat
Antibody Clone CTJS-55
Isotype IgG2a κ
Applications IF; IHC; FC
Host Animal Mouse
Specie Reactivity Human; Mouse; Rat
Antibody Clone CTJS-55
Isotype IgG2a κ
Applications WB; IF; IHC; FC
Host Animal Mouse
Specie Reactivity Human; Mouse; Rat
Antibody Clone CTJS-55
Isotype IgG2a κ
Applications WB; IF; IHC; FC
Host Animal Mouse
Specie Reactivity Human; Mouse; Rat
Antibody Clone CTJS-55
Isotype IgG2a κ
Applications WB; IF; IHC; FC
Host Animal Mouse
Specie Reactivity Human; Mouse; Rat
Antibody Clone CTJS-55
Isotype IgG2a κ
Applications WB; IF; IHC; FC
Host Animal Mouse
Specie Reactivity Human; Mouse; Rat
Antibody Clone CTJS-55
Isotype IgG2a κ
Applications WB; IF; FC
Host Animal Mouse
Specie Reactivity Human; Mouse; Rat
Antibody Clone CTJS-55
Isotype IgG2a κ
Applications WB; IF; FC
Host Animal Rat
Specie Reactivity Mouse
Antibody Clone CTJS-676
Isotype IgG2a
Applications FC; CyTOF; ELISA
Host Animal Rat
Specie Reactivity Mouse
Antibody Clone CTJS-676
Isotype IgG2a
Applications FC; ELISA
Host Animal Rat
Specie Reactivity Mouse
Antibody Clone CTJS-676
Isotype IgG2a
Applications FC; ELISA
Host Animal Rat
Specie Reactivity Mouse
Antibody Clone CTJS-676
Isotype IgG2a
Applications FC; ELISA
Host Animal Rat
Specie Reactivity Mouse
Antibody Clone CTJS-676
Isotype IgG2a
Applications FC; ELISA
Host Animal Rat
Specie Reactivity Mouse
Antibody Clone CTJS-676
Isotype IgG2a
Applications FC; ELISA
Host Animal Rat
Specie Reactivity Mouse
Antibody Clone CTJS-676
Isotype IgG2a
Applications FC; ELISA
Host Animal Rat
Specie Reactivity Mouse
Antibody Clone CTJS-676
Isotype IgG2a
Applications FC; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-875
Isotype IgG2a
Applications FC; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-875
Isotype IgG2a
Applications FC; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-875
Isotype IgG2a
Applications FC; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-875
Isotype IgG2a
Applications FC; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-875
Isotype IgG2a
Applications FC; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-875
Isotype IgG2a
Applications FC; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-875
Isotype IgG2a
Applications FC; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-875
Isotype IgG2a
Applications FC; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone CTJS-875
Isotype IgG2a
Applications FC; ELISA
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-179
Isotype IgG2a
Applications Flow
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-179
Isotype IgG2a
Applications Flow
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-179
Isotype IgG2a
Applications Flow
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-179
Isotype IgG2a
Applications Flow
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-179
Isotype IgG2a
Applications Flow
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-179
Isotype IgG2a
Applications Flow
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-179
Isotype IgG2a
Applications Flow
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-179
Isotype IgG2a
Applications Flow
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-179
Isotype IgG2a
Applications Flow
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-179
Isotype IgG2a
Applications Flow
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-179
Isotype IgG2a
Applications Flow
Host Animal Mouse
Specie Reactivity Human
Antibody Clone TJL-179
Isotype IgG2a
Applications Flow
Specie Reactivity Human
Sensitivity 6.25 pg/mL (25-1600 pg/mL)
Applications ELISA
Specie Reactivity Human
Sensitivity 0.188 ng/mL (0.313-20 ng/mL)
Applications ELISA
Specie Reactivity Mouse
Sensitivity 0.094 ng/mL (0.156-10 ng/mL)
Applications ELISA
Specie Reactivity Rat
Sensitivity 0.375 ng/mL (0.625-40 ng/mL)
Applications ELISA
Specie Reactivity Ovine
Sensitivity 5.625 ng/mL (9.375-600 ng/mL)
Applications ELISA
Clear All
Specie Reactivity Human
Type Recombinant Protein
Expression Host Wheat Germ (in vitro)
Applications WB; ELISA; PA; AP
Specie Reactivity Human
Type Recombinant Protein
Expression Host Wheat Germ (in vitro)
Applications AP
Specie Reactivity Human
Type Recombinant Protein
Expression Host HEK293T Cells
Applications WB; ELISA; PA
Specie Reactivity Human
Type Recombinant Protein
Expression Host Insect Cells
Applications ELISA; WB
Specie Reactivity Mouse
Type Recombinant Protein
Expression Host E.coli
Applications ELISA; WB
Specie Reactivity Mouse
Type Recombinant Protein
Expression Host Insect Cells
Applications ELISA; WB
Specie Reactivity Human
Purity >90%
Applications Blocking; WB
Specie Reactivity Human
Purity >90%
Applications Blocking; WB
[Cat#: CTI-001] SB290157 (Trifluoroacetate)
CAS No. 1140525-25-2
Solubility DMSO: 125 mg/mL (Need ultrasonic)
Product Overview This product is a potent C3a receptor antagonist, it selectively inhibits C3aR with the IC50 of 200 nM.
Specie Reactivity Human
Species of Lysate 293T Cells
Application Western Blotting (WB)
Specie Reactivity Human
Species of Lysate Human Cells
Application Western Blotting (WB)
Product List Background

Background

C3aR, also known as C3a receptor, is a single polypeptide chain that spans the membrane seven times, belonging to the family of G-protein-coupled receptors (GPCRs). The receptor contains a large second extracellular loop of approximately 175 amino acids compared to about 30 amino acids for most GPCRs including the C5a receptor and FPR family. This loop has been revealed to play a role in C3a binding and receptor activation.

C3aR is primarily found on myeloid and lymphoid cells. It serves as a key chemotactic mediator in the immune system. C3aR interacts with C3a polypeptides (the best known as chemotactic and inflammatory cytokines) to facilitate the movement of neutrophils, monocytes, and macrophages to the site of inflammation, where they promote the phagocytosis of opsonized foreign molecules and altered self molecules. C3aR also acts as an immune checkpoint receptor. Complement signaling through C3aR expressed on effector T lymphocytes inhibits the production of the cytokine interleukin-10 (IL-10). In various inflammatory-related diseases, C3aR signaling exhibits a protective role. For example, C3aR signaling has been revealed to act as a potent regulator of ethanol-induced adipose inflammation in a murine model with alcohol-related liver disease (ALD). C3aR signaling has been also shown a protective role in the development of atherosclerosis through negative regulation of proinflammatory responses regulated by the C3a-C3aR axis and regulating the macrophage toward the anti-inflammatory phenotype.

Proposed interaction between FcεRI and C3aR leading to mast cell activation. Fig.1 Proposed interaction between FcεRI and C3aR leading to mast cell activation. (Ali, 2005)

Reference

  1. Ali, H.; et al. Anaphylatoxin C3a receptors in asthma. Respiratory Research. 2005, 6: 19.
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For Research Use Only.