Stem Cell-derived Exosomes and Their Applications
- Common Sources
Overview Services Features FAQs
Creative Biolabs has gained expertise in the exploration and application of various sources of SC-Exo (Stem cell exosomes), offering bespoke services to fulfill the objectives of client SC-Exo projects.
Variations Among Distinct Types of SC-Exo
Since they mirror the characteristics of the source cells, distinct varieties of SC-Exo differ from others. The two most often studied types of exosomes are those produced by MSC (mesenchymal SCs) and CSC (cancer SCs).
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We summarize the progress of SC-Exo from the following multiple sources and can provide the comprehensive SC-Exo research services you require.
SC-Exo
SC-Exo Identification and Omics Profiling Strategies
Effective identification of SC-Exo after isolation is a prerequisite and basis for conducting subsequent studies. The ability to secrete exosomes has been discovered to be highest in SCs, and they can control the release of exosomes through a particular signaling axis. Refinement of identification and profiling facilitates the traceability of SC-Exo and its inheritance from the parent cell with associated advantages and applications.
Fig. 1 Three SC-Exo diverse protein and miRNA landscapes.1
SC-Exo of multiple origins can act as paracrine mediators by exchanging unique genetic details with other cells. Creative Biolabs is a reliable partner for advancing your SC-Exo related projects. Please contact us to discuss your project.
FAQs
Q: What types of stem cells are commonly used to produce exosomes?
A: Common sources of stem cell-derived exosomes include ESCs, iPSCs, MSCs, and NSCs. Exosomes with distinct characteristics and possible uses are produced by all varieties of stem cells.
Q: How do stem cell-derived exosomes contribute to regenerative medicine?
A: Exosomes from stem cells can promote tissue repair and regeneration by delivering bioactive molecules that enhance cell proliferation, reduce inflammation, and stimulate angiogenesis in damaged tissues.
Q: What benefits do exosomes offer over stem cells?
A: Exosomes have several benefits, such as the capacity to pass across biological barriers like the blood-brain barrier, a decreased chance of immunological rejection, and ease of handling and storage. Additionally, exosome-based approaches may reduce the risk of tumorigenesis associated with stem cell transplantation.
Q: What distinguishes stem cell-derived exosomes from exosomes produced by other cell types?
A: Exosomes from stem cells often have unique regenerative and immunomodulatory properties not found in exosomes from other cell types. The kind of stem cell, the conditions in the culture, and the separation techniques can all affect their makeup and functionality.
Reference
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Bi, Youkun, et al. "Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells." Stem Cell Research & Therapy 13.1 (2022): 449. Under open access license CC BY 4.0. The image was modified by extracting and using only parts of the original images, and by revising the title.
For Research Use Only. Cannot be used by patients.
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