Stem Cell-derived Exosome Application
- Menstrual Blood MSC Source
Emerging Menstrual Blood Mesenchymal Stem Cell-derived Exosomes (MBMSC-Exos)
Mesenchymal stem cells from menstrual blood (MBMSCs) are a novel form of stem cell that exhibit the properties of mesenchymal stem cells (MSCs) found in human menstrual blood. The collection of MBMSCs avoids moral dilemmas and invasive procedures because menstrual blood is accessible throughout a woman's menstrual cycle. This simple accessibility makes it possible to gather lots of MBMSCs. Under the right stimulation, MBMSCs can develop into bone cells, fat cells, chondrocytes, liver cells, cardiomyocytes and other cells in addition to quickly proliferating. Due to these benefits, MBMSCs are a desirable replacement for MSCs derived from different sources, such as bone marrow or adipose tissue.
Recent research has shown that MBMSCs effectively release a variety of bioactive compounds, particularly exosomes formed from MBMSCs (MBMSC-Exos). MBMSC-Exos effectively expands the knowledge pertaining to tissue regeneration and immunological modulation in MBMSCs as a key carrier of MBMSC secretory activity. After MBMSC-Exos are internalized by target cells and have an impact on the behavior of target cells, such as proliferation, migration, differentiation, etc., this information will be communicated to the target cells. As a result, MBMSC-Exos, which has enormous therapeutic potential and future application prospects, has progressively grown to become one of the most well-known stem cell exosomes. The benefits of MBMSC-Exos interested Creative Biolabs as well, and they evaluated how it might be used in the field of cell-free therapy.
Fig.1 The strategy for developing clinical applications of MenSC-derived small EVs.1,2
MBMSC-Exos Potential in Cell-free Therapy Field
Repairing tissue: MBMSC-Exos
Inherit the pro-regenerative properties of their parent cells, showing promising results in promoting tissue regeneration and wound healing. In terms of neural repair, MBMSC-Exos can significantly promote the growth of neuronal processes and axons. In tissue-interstitial repair, MBMSC-Exos can reduce inflammatory activation, oxidative stress, and apoptosis in a rat model of lung fibrosis through its own miRNA let-7. Likewise, MBMSC-Exos can improve liver function and slow down the progression of liver failure by inhibiting the apoptosis of hepatocytes. In addition, MBMSC-Exos can restore the regeneration of β-cell mass and promote insulin synthesis through Pdx-1 signaling, which provides a new candidate for the treatment of type 1 diabetes. In terms of wound healing, MBMSC-Exos promote wound healing by regulating macrophage polarization and collagen synthesis.
Regulating tumor progression
MBMSC-Exos have been shown to inhibit ROS-dependent tumor angiogenesis by reducing ROS synthesis in prostate cancer cells, thereby slowing down tumor growth. Similarly, MBMSC-Exos can induce apoptosis of vascular endothelial cells by inhibiting the secretion of vascular endothelial growth factor in oral squamous cell carcinoma cells, thereby effectively interfering with tumor angiogenesis. The anti-vascular remodeling effect of MBMSC-Exos provides a new strategy for tumor therapy.
Regulating reproductive function
MBMSC-Exos has a powerful reproductive regulating function because it is derived from menstrual blood. MBMSC-Exos significantly promoted follicle development, the awakening of dormant follicles, the proliferation of granulosa cells, and the synthesis of the ovarian extracellular matrix, thereby improving ovarian function. In addition, MBMSC-Exos enhanced embryonic development by regulating ROS-related signaling pathways. This provides a new research direction for improving female fertility.
In conclusion, MBMSC-Exos has broad application prospects in regenerative medicine, cancer therapy, and the promotion of reproduction. Their non-invasive and easy-to-collect nature, the abundance of bioactive components, stable lipid bilayer membrane, and small size make them ideal tools for therapeutic intervention. Ongoing research will undoubtedly reveal further applications of MBMSC-Exos and their revolutionary impact on modern medicine. Creative Biolabs has specialized in exosome research and development for many years and has established a comprehensive exosome research technology platform. If you want to transform the potential of exosomes in disease treatment, please contact us and leave your ideas or needs.
References
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Chen, L.; et al. Small extracellular vesicles from menstrual blood-derived mesenchymal stem cells (MenSCs) as a novel therapeutic impetus in regenerative medicine. Stem Cell Research & Therapy. 2021, 12(1):433.
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under Open Access license CC BY 4.0, without modification.
For Research Use Only. Cannot be used by patients.
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