Stem Cell-derived Exosome Application
- Embryonic Source

Overview Services Features FAQs

ESCs-Exo (embryonic stem cell-derived exosomes) is a less common area of research, associated with lower rates of ESC research. However, some noteworthy published results are showing the potential of multi-directional ESCs-Exo applications. Creative Biolabs summarizes the applications of ESCs-Exo, providing exosome research services to expand the horizon of applied ESCs-Exo.

ESCs-Exo Applications

Promoting angiogenesis

Proteomic analysis of ESCs-Exo showed that it contains fibroblast growth factor FGF2 protein, which induces angiogenesis to attenuate heart failure models in mice.

Fig.1 ESCs-Exo promote angiogenesis via FGF2. Fig.1 ESCs-derived exosomes stimulate angiogenesis in an FGF2 related way.¹

Promoting cell proliferation

The miRNA array of ESCs-Exo showed significant enrichment and specific transfer of miR-294 to enhance the proliferation of cardiac progenitor cells in a mouse model of myocardial infarction.

Fig.2 ESCs-Exo enhance MSC proliferation. Fig. 2 ESCs-Exo can improve MSC cell proliferation.²

Reduced inflammation

ESCs-Exo reduced cardiomyocyte focal death factor levels, enhanced macrophage-associated anti-inflammatory phenotype, and inhibited cytoplasmic vacuolization and myogenic fiber loss.

Fig.3 ESCs-Exo provide anti-inflammatory benefits. Fig. 3 ESCs-Exo deliver anti-inflammatory effects.³

Regulating senescence

ESCs-Exo transferred miR-200a to senescent endothelial cells and activated Nrf2 signaling to improve endothelial senescence.

Fig.4 ESCs-Exo trigger anti-aging mechanisms. Fig. 4 ESCs-Exo activate anti-aging pathways.⁴

ESCs-Exo Application Potential Research Case

The tumor suppressive potential of ESCs-Exo and its mechanism have been demonstrated. One study applied ESCs-Exo modified with brain-targeting peptides to achieve targeted delivery of loaded chemotherapeutic agents to the focal area and to significantly increase the system's antitumor efficacy.

ESCs and ESCs-Exo

Creative Biolabs, as an autonomous and innovative exosome research company, has been providing ESCs-Exo related research and application services firmly for a long time. Please contact us to get reliable solutions.

FAQs

Q: What are stem cell-derived exosomes, and how are they related to embryonic sources?

A: Stem cell-derived exosomes are nanoscale vesicles released by stem cells, including those derived from embryonic sources. ESCs are special because they can differentiate into any type of cell in the body and can self-renew. When derived from embryonic stem cells, exosomes may carry factors that promote regeneration, repair, or immune modulation.

Q: Why are exosomes generated from embryonic stem cells particularly interesting for therapeutic uses?

A: Because they can replicate the therapeutic effects of stem cells without the moral dilemmas and safety dangers associated with direct stem cell transplantation, ESCs-Exo hold enormous promise for therapeutic development. These exosomes are appealing possibilities for a variety of disorders because they may be able to influence immune responses, promote tissue repair, and transmit regenerative messages to damaged tissues.

Q: How should embryonic stem cell-derived exosomes be stored?

A: For these exosomes to remain stable and biologically active, storage should be done at -80°C. They should be handled carefully to avoid repeated freeze-thaw cycles, which can degrade the exosomes.

Q: Can embryonic stem cell-derived exosomes be used in cosmetic applications?

A: There is growing interest in the use of stem cell-derived exosomes, including those from embryonic sources, in cosmetics for their potential to promote skin rejuvenation and repair.

Q: Are there any safety concerns or challenges associated with using embryonic stem cell-derived exosomes?

A: While the therapeutic potential is promising, several challenges remain:

Immunogenicity: Ensuring that exosomes do not elicit immune rejection in recipients.
Standardization: Developing consistent and reproducible manufacturing processes for exosomes.
Long-term Effects: Comprehending the safety and effectiveness of exosome-based treatments over the long run.
Ethical Considerations: Addressing ethical concerns related to the use of embryonic stem cells, although exosome therapies may circumvent some of these issues by focusing on the end product rather than the stem cells themselves.

References

Pang, Yanan, et al. "" Frontiers in Cardiovascular Medicine 8 (2021): 638771. Under open access license CC BY 4.0. The image was modified by extracting and using only part C and D of the original image, and by revising the title.
Zhang, Yan, et al. "Embryonic stem cell-derived extracellular vesicles enhance the therapeutic effect of mesenchymal stem cells." Theranostics 9.23 (2019): 6976. Under open access license CC BY 4.0. The image was modified by revising the title.
Singla, Dinender K., Taylor A. Johnson, and Zahra Tavakoli Dargani. "Exosome treatment enhances anti-inflammatory M2 macrophages and reduces inflammation-induced pyroptosis in doxorubicin-induced cardiomyopathy." Cells 8.10 (2019): 1224. Under open access license CC BY 4.0. The image was modified by revising the title.
Chen, Bi, et al. "Human embryonic stem cell-derived exosomes promote pressure ulcer healing in aged mice by rejuvenating senescent endothelial cells." Stem Cell Research & Therapy 10 (2019): 1-17. Under open access license CC BY 4.0. The image was modified by extracting and using only part I of the original image.