Stem Cell-derived Exosome Application
- Umbilical Cord Blood Mesenchymal Source
Overview Services Features FAQs
UCBMSC-Exo (Umbilical cord blood MSC-derived exosomes) has promising applications due to its low immunogenicity, rich functional elements, and high engineering modifiability. Creative Biolabs has accumulated insights into the characteristics and applications of UCBMSC-Exo and provides a comprehensive solution for exosome research.
Applications of UCBMSC-Exo
Fig. 1 UCBMSC-Exo stimulates regenerative wound healing.1
What We Offer
At our research facility, we provide cutting-edge solutions utilizing stem cell-derived exosomes, specifically from UCBMSCs. Our offerings include:
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High-Quality Exosome Isolation: We utilize advanced techniques to isolate exosomes from UCBMSCs, ensuring high purity and yield for research applications.
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Characterization Services: Comprehensive characterization of exosomes, including size distribution, concentration, and surface marker analysis, to confirm their identity and functionality.
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Customized Research Solutions: Tailored experimental designs to meet specific research needs, including analysis applications, drug delivery systems, and biomarker discovery.
UCBMSC-Exo Features
Creative Biolabs supports the processing of exosome samples from multiple sources, including UCBMSC, and continues to introduce innovative service platforms. Please contact us to learn more.
FAQs
Q: Why use UCBMSCs?
A: UCBMSCs are an abundant and potent source of stem cells that exhibit remarkable qualities, such as a high rate of proliferation and the ability to differentiate into multiple cell types. They can be used in allogeneic transplantation because of their low immunogenicity, which reduces the possibility of immunological rejection in recipients. Additionally, UCBMSCs are non-controversial compared to other sources like embryonic stem cells. Their regenerative properties and demonstrated success in preclinical and clinical studies make them particularly promising for a wide range of therapeutic applications, including tissue repair, immune modulation, and, notably, exosome research.
Q: How are UCBMSC-Exos isolated?
A: UCBMSC-Exos are typically isolated using various advanced techniques designed to ensure the integrity and purity of the exosomes. Common methods include ultrafiltration, which separates exosomes based on size, and precipitation, where specific reagents are used to aggregate and collect exosomes from culture media. Another highly effective approach is affinity-based isolation, which relies on specific interactions between surface markers on exosomes and capture antibodies.
Q: Do the exosomes contain any cellular material or DNA?
A: No, exosomes do not contain significant amounts of cellular debris or potentially harmful material. During the purification process, they are filtered and isolated to ensure the output primarily consists of exosomes and their naturally associated bioactive molecules, including proteins and RNAs.
References
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Zhang, Yan, et al. "Exosomes derived from human umbilical cord blood mesenchymal stem cells stimulate regenerative wound healing via transforming growth factor-β receptor inhibition." Stem cell research & therapy 12 (2021): 1-14. Under open access license CC BY 4.0. The image was modified by revising the title.
For Research Use Only. Cannot be used by patients.
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