Lactobacillus plantarum-derived Exosome Research and Application

Lactobacillus plantarum, a type of probiotic, belongs to the Lactobacillus genus. It is widely distributed in nature, particularly playing a crucial role in fermented foods and the food industry. Apart from its applications in the food industry, Lactobacillus plantarum has piqued significant interest in the biomedical field due to its potential health benefits.

What's even more exciting is that recent research suggests that exosomes produced by Lactobacillus plantarum may have positive effects in various areas, including improving gut health, regulating the immune system, and preventing diseases. Creative Biolabs, as an advanced exosome technology service provider, is keenly aware of the biomedical applications and new opportunities in probiotic therapy brought about by Lactobacillus plantarum-derived exosome research. Exploration in this field holds promise for enhancing human health.

Exosomes Derived from Lactobacillus plantarum Have Various Potential Benefits

Improving Skin:

1. Alleviating Atopic Dermatitis: Exosomes derived from Lactobacillus plantarum can reduce allergic inflammatory responses, decrease epidermal thickening caused by other pathogens, and mitigate pro-inflammatory effects.

2. Anti-Aging: Lactobacillus plantarum-derived exosomes reduce wrinkle formation and pigmentation deposition by regulating matrix metalloproteinase-1 and mRNA expression of matrix-related genes.

3. Anti-Inflammatory Effects: Lactobacillus plantarum-derived exosomes regulate surface markers and cell cytokines associated with M2 macrophages, reducing excessive skin inflammation.

Improving Gut:

1. Alleviating Ulcerative Colitis: Exosomes from Lactobacillus plantarum reduce inflammatory responses, including intestinal shortening, bleeding, and weight loss, improving symptoms of ulcerative colitis. Furthermore, they adjust the imbalance in the gut microbiome, increasing diversity and reducing the content of inflammatory bacteria (Proteobacteria) while enhancing the proportion of anti-inflammatory bacteria.

2. Restoring Chemotherapy Sensitivity in Colon Cancer: Exosomes derived from Lactobacillus plantarum were found to reverse resistance to 5-fluorouracil (5-FU) in colon cancer cells to some extent by reducing PDK2 expression, increasing sensitivity to chemotherapy.

3. Regulating Gut Immunity: Exosomes from Lactobacillus plantarum were found to induce macrophages to produce various types of cytokines, including pro-inflammatory and anti-inflammatory cytokines, and promote the production of immunoglobulin A by immune gland cells. This suggests that Lactobacillus plantarum-derived exosomes can activate both innate and adaptive immune responses, positively impacting the gut immune system.

Improving Nervous System Function:

1. Alleviating Depression: Injections of exosomes derived from Lactobacillus plantarum can prevent the expression decrease of BDNF and Nt4/5 before each stressor, alleviating stress-induced depressive symptoms.

2. Repairing Brain Ischemic Injury: Lactobacillus plantarum-derived exosomes reduce neuronal apoptosis and aid in neurorecovery in brain ischemia patients by regulating the miR-101a-3p/c-Fos/TGF-β pathway.

Specialized Services at Creative Biolabs

Exosomes from Lactobacillus plantarum show broad prospects for application in various medical and health-related fields. Creative Biolabs offers microbiome-derived exosome research services in this field. Please contact us for essential support.

Bacteria-derived Exosome Isolation and Identification

In Vitro Functional Discovery of Bacteria-derived Exosomes

In Vivo Functional Discovery of Bacteria-derived Exosomes

Target Screening (Proteins, RNA, Lipids and Metabolites) of Host

Target Analysis of Host

References

Echegaray, N.; Yilmaz, B.; et al. A novel approach to lactiplantibacillus plantarum: from probiotic properties to the omics insights. Microbiological Research. 2023. 268:127289.
Kim, MH.; Choi, SJ.; et al. Lactobacillus plantarum-derived extracellular vesicles protect atopic dermatitis induced by staphylococcus aureus-derived extracellular vesicles. Allergy Asthma & Immunology Research. 2018. 10(5):516-532.
Kurata, A.; K Kiyohara, S.; et al. Characterization of extracellular vesicles from lactiplantibacillus plantarum. Scientific Reports. 2022. 12(1):13330.
Yang, Z.; Gao, Z.; et al. Lactobacillus plantarum-derived extracellular vesicles protect against ischemic brain injury via the microRNA-101a-3p/c-Fos/TGF-β axis. Pharmacological Research. 2022. 182:106332.