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Creative Biolabs is a world-leading service provider in glycoprotein analysis services for global customers based on our most comprehensive and advanced technical platform. Our service program covers every step of glycoprotein analysis from glycan release to glycan identification. We have developed a series of technologies for glycan analysis, from which you can choose an optimal analytical strategy to meet your project.
The presence, absence, and profile of the complex oligosaccharide moieties on the biopharmaceuticals, such as monoclonal antibodies (mAbs), have an essential effect on their therapeutic efficacy, pharmacokinetics, immunogenicity, folding, and stability. To better analysis of glycoform and glycomics, most techniques have been developed. Typical glycoprotein analysis techniques include lectin microarray, mass spectrometry (MS), high-performance liquid chromatography (HPLC) on various solid phases. MS is coupled with different separation methods, such as capillary electrophoresis (CE) and liquid chromatography (LC) used for glycoprotein analysis. Some detection methods are also used for glycan analysis such as pulsed amperometric detection (PAD) and fluorescence detection (FLD). The following picture shows the common methods applied for glycoprotein analysis.
The selection of appropriate methods for a specific glycoprotein is determined by the purpose of detection and the capacity of individual technique in analyzing intact glycoproteins, glycopeptides, released glycans, and monosaccharides. With years of experience in glycoproteins analysis, Creative Biolabs has established a variety of technical platforms for glycoprotein analysis including number and location of N- and O-linked glycosylation sites identification, the degree of glycosylation site occupancy detection, characterization of oligosaccharide structure, sialic acid content and type, etc. We are confident in offering comprehensive glycoprotein analysis services for global customers based on our diverse technical platforms. Our glycoprotein analysis services include Glycoprotein Detection, Glycoprotein Structure Analysis, and Glycoprotein Quantification. Besides, our excellent experts can also provide detailed technical guidance and help our customers formulate an optimal analysis protocol to accelerate the later research.
Techniques | Advantages in Glycan Analysis |
Lectin Microarray |
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MS |
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LC-ESI-MS |
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MALDI-TOF MS |
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GC-MS |
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HPLC |
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HPAEC-PAD |
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RP-HPLC |
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UHPLC/FLD/Q-TOF |
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FTIR |
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NMR |
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SPRi |
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TLC |
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Flow Cytometry |
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Equipped with various technologies and experienced expert staff, Creative Biolabs is proud to offer the most comprehensive glycan analysis. Over the past several years, Creative Biolabs wins high praise from all over the world. We believe that our best services will promote your project success. If you are interested in our services, please don’t hesitate to contact us for more information and a detailed quote. If you have some puzzles in glycoprotein analysis, let us know and we will assist you.