Recombinant HHV-5 (strain AD169) Envelope glycoprotein B (gB), E. coli (CAT#: GPX-146-E-J)

Product Overview	Recombinant Human herpesvirus 5 (strain AD169) (HHV-5) Envelope glycoprotein B was expressed in E. coli with a His-tag or Tag free. The biological activity was determined by its binding ability in a functional ELISA. This product can be used in ELISA, WB, and IP.
Biological Activity	Determined by its binding ability in a functional ELISA.
Source	E. coli
Species	Human herpesvirus 5 (strain AD169) (HHV-5)
Tag	His-tag or Tag free
Purity	>90%, determined by SDS-PAGE.
Conjugation	Unconjugated

Target	gB
Full Name	Envelope glycoprotein B
Uniprot ID	P13201
Background	Envelope glycoprotein that plays a role in host cell entry, cell to-cell virus transmission, and fusion of infected cells. May be involved in the initial attachment via binding to heparan sulfate together with the gM/gN complex that binds heparin with higher affinity. Interacts with host integrin ITGB1, PDGFRA and EGFR that likely serve as postattachment entry receptors. Participates also in the fusion of viral and cellular membranes leading to virus entry into the host cell. Membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL.
Alternate Names	Envelope glycoprotein B; gB