Anti-Microbial Enzyme Antibody Products

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Creative Biolabs is a complete antibody solutions provider that offers unmatched quality antibodies. Providing the best antibody products is just the beginning, we ensure that every customer receives our utmost attention.

Overview

Antibodies are one of the most valuable macromolecules in life science research and have been applied in many biomedical disciplines, such as biotechnology, immunotherapy, diagnostics, and medicine. They can specifically bind a large range of chemical structures and use the same type of molecular interactions. Anti-bacterial monoclonal antibody drug development is still in its infancy and is gaining increasing interest.

Enzymes mediate a variety of intracellular biological events, such as energy metabolism, macromolecular synthesis, anabolic processes, cell signal transduction and. Enzyme inhibitors have been shown to have a significant impact in many biological and therapeutic areas, such as neurological disorders, birth control, lysosome storage diseases, and skin diseases. In most cases, the interaction of an enzyme with its specific antibody results in a decrease in its enzyme activity in vitro. Antibodies can act as inhibitors by altering the structure of enzymes. These activities are known as the cognitive effects function of antibodies because in these cases the antibody recognition process results in direct functional changes of the target molecule.

It is also important to consider the optimal degree of enzyme-induced immune response when selecting antibodies as enzyme inhibitors. Interactions between enzymes and their specific antibodies usually result in a decrease in enzyme activity.

Mechanisms of Enzyme Inhibition by Antibodies

The inhibition of enzymes by antibodies can occur through several mechanisms. The extent to which an enzyme can be inhibited or enhanced by an antibody is determined by the type and distribution of different antigenic determinants on the enzyme molecule.

  • Steric Hindrance at the Active Site

Antibodies that bind to or are adjacent to the active site of an enzyme are expected to compete with the substrate for that site and inhibit enzyme activity through steric hindrance.

  • Inducing Aggregation That Interferes with Substrate Access to the Catalytic site

Antibo-induced enzyme aggregation can promote steric hindrance by interfering with substrate access to catalytic sites.

  • Induction of Conformational Changes That Modify the Enzymatic Activity

Antibodies can also indirectly inhibit enzymes by binding to "regulatory sites" away from the active site, where antibodies interact to cause conformational changes in the enzyme.

  • Targeting Regulatory Sites that Regulate the Enzymatic Activity
  • Combined Mode of Action

Different mechanisms of enzyme inhibition by antibodies Fig.1 Different mechanisms of enzyme inhibition by antibodies. (De, 2021)

Related Anti-Microbial Protein Antibody Products

Anti-Enzyme Abs
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Anti-Membrane Protein Abs
Anti-Flagellin Abs
Anti-Skeleton Protein Abs
Anti-Photosynthetic Protein Abs
Anti-Photosensitive Protein Abs

The Creative Biolabs team is a diverse, knowledgeable, and flexible team with solid leadership that is universally recognized in the antibody community. With our effective tools, extensive knowledge, and unwavering support, we ensure that our partners can successfully launch products. If you are interested in our anti-microbial enzyme antibody products, please contact us for more details.

Reference

  1. De, L.L.; et al. Antibodies targeting enzyme inhibition as potential tools for research and drug development. Biomolecular Concepts. 2021, 12(1): 215-232.

For Research Use Only. Do NOT use in humans or animals.

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