Anti-Microbial Protein Antibody Products

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Creative Biolabs focuses on research in the field of antibodies. Our team of highly qualified and experienced technicians works together to develop and test products to ensure the high efficiency of antibody products.

Overview

Highly conserved exopolysaccharides, pilus-forming proteins, and extracellular vesicle components are essential for bacterial pathogenesis and have also been investigated as immunotherapeutic targets. With a large number of antibodies and antibody drug conjugations already approved or on the verge of being approved for cancer treatment, targeted therapies are becoming increasingly attractive. With an in-depth understanding of target antigens and their pathogenic roles, anti-bacterial monoclonal antibodies against antibiotic-resistant pathogens have enormous potential. Numerous antimicrobial monoclonal antibodies (mAbs) are being explored in preclinical research. The main advantages of mAbs are an optimal selection of antibody targets and high specificity, thus reducing the selection pressure for off-target effects and cross-resistance. Antibodies that target surface components of bacteria may prevent pathogens from establishing infections by blocking their binding sites, adhering to, and invading host cells. This effect is reflected in the growth rate and survival rate of bacteria in vitro.

Antibodies were invented by nature primarily to fight infections caused by microorganisms. To identify new possible antibody targets, we must extend our understanding of bacteria’s virulence factors and pathogenic mechanisms. Despite the redundancy and complexity of the virulence factors and pathogenic pathways, the antibody cocktail and bispecific or even multispecific antibodies appear to be possible solutions.

Antibodies Targeting Bacterial Surface Components

Surface antigens have been popular targets for antimicrobial antibody discovery. The main modes of action of antibacterial antibodies are viral factor neutralization, complement-mediated bacterial lysis, and enhanced phagocyte uptake and killing (OPK). The molecular targets of anti-bacterial mAbs can be classified into two major classes. Antibodies against secretory bacterial components are designed to neutralize exotoxins or other secretory virulence factors, while antibodies against bacterial surfaces often promise to induce bactericidal activity in different ways.

Overview of potential bacterial target antigens. Fig.1 Overview of potential bacterial target antigens. (Nagy, 2017)

Creative Biolabs’ Anti-Microbial Protein Antibody Products

Anti-Enzyme Abs
Anti-Toxin Abs
Anti-Membrane Protein Abs
Anti-Flagellin Abs
Anti-Skeleton Protein Abs
Anti-Photosynthetic Protein Abs
Anti-Photosensitive Protein Abs

At Creative Biolabs, we have extensive experience in antibody development. We use our state-of-the-art R&D and manufacturing expertise to help our customers develop outstanding products. If you are interested in our antibody products, please do not hesitate to contact us.

Reference

  1. Nagy, E.; et al. Anti-bacterial monoclonal antibodies. Recombinant Antibodies for Infectious Diseases. 2017: 119-153.

Hot Products

A. australis Aa6 A. australis AaHI A. australis AaHII A. pernix KvAP AflaToxin AflaToxin B1 B. anthracis Anthrax LF B. anthracis BclA B. anthracis EAl protein B. anthracis PA B. burgdorferi OspA B. burgdorferi OspB B. pseudomallei Protease B. rubescens MBG B. subtilis RNaseY

For Research Use Only. Do NOT use in humans or animals.

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