Anti-Microbial Membrane Protein Antibody Products

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Introduction of Membrane Protein

Cell surface membrane proteins comprise a wide array of structurally and functionally diverse proteins involved in a variety of important physiological and homeostatic processes. Complex global membrane proteins are embedded in the lipid bilayer through multiple transmembrane helices and are important target protein families for drug discovery. Outer membrane proteins (OMPs), as an important virulence factor in bacteria, have attracted increasing attention. OMPs are a unique class of complete membrane proteins immobilized in OM, whose β-barrel structure consists of 8-26 chains. There are large, extended rings between the chains outside the cell and short rings between the chains outside the plasma. These properties give OMPs high stability in membranes and the ability to withstand extremely harsh environments. Although different OMPs have different sequences and functions, they share similar structures and biological characteristics. The diversity of the OMPs sequence is significantly greater at the N terminal than at the C terminal, and the conserved β signal controls the folding and correct assembly of OMPs.

OmpA Structure and Function

OmpA is the most well-studied virulence factor, which plays a key role in the adhesion, invasiveness, biofilm formation, and host immune response of A. baumannii. The OmpA family is a group of surfacing exposed high copy number pore proteins of Gram-negative bacteria (GNB) Omps. The N-terminal domain of OmpA is an antiparallel β-barrel structure consisting of 8 transmembrane strands embedded in the outer membrane. The integral OMPs are essential for maintaining the integrity and selective permeability of bacterial membranes. Some of them serve as adhesins and play an important role in virulence. Outer membrane proteins are extremely immunogenic and therefore they would be effective candidates for vaccine and diagnostic development owing to their exposed epitopes on the cell surface. Therefore, the generation of antibodies specific against the surface and structural components might prevent the establishment of infection.

Diverse topologies of complex membrane proteins and interactions with antibodies. Fig.1 Diverse topologies of complex membrane proteins and interactions with antibodies. (Dodd, 2018)

MAb Therapeutic Strategies Targeting AbOmpA

Antibodies can also bind to receptor targets on the cell surface, inhibiting the action of pathophysiological mediators or causing stimulation of signaling pathways. It is widely believed that antibodies can be used to defend against microbial infections. Passive immunity induced by antibodies targeting AbOmpA has been proposed as a potential treatment for MDR and XDR-A. baumannii infection. Monoclonal antibody (mAb) technology contributes to the development of antibacterial mAbs, mAbs possess more advantages, such as higher safety, better homology, and more specific targets.

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Anti-Membrane Protein Abs
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Creative Biolabs is a leading manufacturer of custom antibodies, having developed tens of thousands of antibodies over the last decade. Our professional scientists and excellent technical support team can provide you with tailor-made, flexible antibody production solutions to meet your needs. If you are interested in our antibody products, please contact us for more details.

Reference

  1. Dodd, R.B.; et al. Therapeutic monoclonal antibodies to complex membrane protein targets: antigen generation and antibody discovery strategies. BioDrugs. 2018, 32(4): 339-355.

For Research Use Only. Do NOT use in humans or animals.

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