Anti-Bacteria Antibody Products

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As a forward-looking researcher as well as a leading custom service provider in the field of antibody discovery, Creative Biolabs has won a good reputation among our worldwide customers for successfully accomplishing numerous challenging projects including the generation of anti-bacterial antibodies.

Introduction of Anti-Bacteria Abs

Ubiquitous in nature, bacteria constitute a large domain of prokaryotic microorganisms. Bacteria also have symbiotic and parasitic relationships with plants and animals and play important roles in many stages of the nutrient cycle. However, some types of bacteria are pathogenic and cause infectious diseases.

The discovery of antibiotics and the development of vaccines have greatly extended the human lifespan and improved the quality of life, but the emergence of antibiotic-resistant superbugs has brought new problems and potential challenges. Furthermore, the development of new antibiotics is lagging behind the emergence and spread of antibiotic resistance. In this case, monoclonal antibodies (mAbs) as novel therapeutic agents have been used to ameliorate infection with remarkable clinical success in several fields. Compared with polyclonal antisera, mAbs always present higher specificity, lower variability, and less cross-reaction.

Mechanisms of Anti-Bacteria Abs

In the treatment of bacterial infections, monoclonal antibodies can act through a variety of different mechanisms, including neutralization of toxins, inhibition of virulence factors, complement-mediated killing activity, and opsonophagocytosis. Till now, three mAbs have been approved by FDA for the treatment of bacterial infection.

  • Toxin neutralization - Anti-toxin antibodies block the binding of the toxin to the receptor thereby preventing structural changes of the toxin and facilitating the formation of immune complexes.
  • Inhibition of virulence factors - Antimicrobial monoclonal antibodies can target virulence factors on the surface of bacteria to hinder pathogenicity.
  • Antibody-mediated complement-dependent killing activity - The Fc region of the antibody can bind to C1q, triggering the classical complement pathway to lyse bacteria.

Modes of actions of anti-bacterial mAbs. Fig.1 Modes of actions of anti-bacterial mAbs. (Wang, 2022)

Anti-Bacteria Abs at Creative Biolabs

For efficient acquisition of antibacterial antibodies, toxins and bacterial surface components are good targets. Based on our extensive experience and advanced platforms, now we can provide a wide range of antibodies against a selection of bacterial species, including Gram-positive bacteria and Gram-negative bacteria. Our antibodies are available in a wide selection of formats (sdAb, IgG, Fab, and scFv) and can be used for applications such as enzyme-linked immunosorbent assay (ELISA), western blotting (WB), immunofluorescence (IF), immunohistochemistry (IHC), etc.

We have created an anti-Organism antibody products inventory to meet all your research needs

Anti-Bacteria Antibody Products Anti-Actinomycete Antibody Products Anti-Spirochete Antibody Products
Anti-Mycoplasma Antibody Products Anti-Rickettsia Antibody Products Anti-Chlamydia Antibody Products
Anti-Microalgae Antibody Products Anti-Protozoa Antibody Products Anti-Archaea Antibody Products
Anti-Parasite Antibody Products Anti-Fungus Antibody Products Anti-Oomycete Antibody Products

Equipped with world-leading technology platforms and professional scientific staff, Creative Biolabs can provide a series of anti-bacterial antibodies. If you are interested in our products, please do not hesitate to contact us for more details.

Reference

  1. Wang, H.; et al. Anti-bacterial monoclonal antibodies: next generation therapy against superbugs. Applied Microbiology and Biotechnology. 2022: 1-16.

For Research Use Only. Do NOT use in humans or animals.

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