Key Details
| Catalog | MAS-0524-YJ48 |
| Applications | ELISA; FuncS |
| Host | Human |
| Reactivity | N. gonorrhoeae |
| Clonality | Monoclonal |
| Conjugations | Conjugation could be customized |
| Sub CAT. | Applications | Clone | Conjugations | Endotoxin Level | Size | Quantity | |
|---|---|---|---|---|---|---|---|
| MAS-0524-YJ48-A | ELISA, FuncS | ch2C7 |
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Overview
Properties
Target
Overview
| Description | Clone ch2C7 is a chimeric (mouse/human) monoclonal IgG recognizes Neisseria gonorrhoeae lipooligosaccharide (LOS). It has a CDC enhancement mutant in Fc region. Greater complement activation by 2C7-E430G Fc translated to increased bactericidal activity in vitro and, consequently, enhanced efficacy in mice, compared with "Fc-unmodified" chimeric 2C7. |
| Reactivity | N. gonorrhoeae |
| Applications | ELISA; FuncS |
| Host | Human |
| Isotype | Chimeric (mouse/human) IgG1 lambda (E430G) |
| Clonality | Monoclonal |
| Clone | ch2C7 |
| Dilutions | ELISA: 0.1-1000 ng/mL |
Properties
| Expression Host | HEK293F/CHO |
| Conjugations | Conjugation could be customized |
| Purification | Protein A/G affinity purified is the regular method |
| Purity | SDS-PAGE> 95% |
| Endotoxin Level | Endotoxin level could be customized |
| Form | Liquid (frequently-used) or lyophilized |
| Concentration | About 1mg/ml. There are differences between batches. Special concentration could be customized. |
| Sterility | 0.2 μM filtered |
| Buffer | See the Datasheet |
| Storage | See the Datasheet |
Target
| Target | N. gonorrhoeae LOS |
| Alternative Names | N. gonorrhoeae; LOS; Neisseria gonorrhoeae; lipooligosaccharide |
| Introduction | Neisseria gonorrhoeae is the second most common bacterial sexually transmitted infection (STI). "2C7 epitope" refers to a highly conserved oligosaccharide structure, a part of lipooligosaccharide (LOS), on Neisseria gonorrhoeae. LOS is a critical component of the outer membrane of Neisseria gonorrhoeae. |
| Organism | Bacteria |
| Related Disease | Gonorrhea |
| Infections Route | Sexual Transmission |
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