Key Details
| Catalog | MAS-0524-YJ2 |
| Applications | ELISA; Neut |
| Host | Human |
| Reactivity | C. difficile |
| Clonality | Monoclonal |
| Conjugations | Conjugation could be customized |
Overview
Properties
Target
Overview
| Description | Clone OA40A, A-C9, rA-C2 are Human monoclonal IgGs recognize C. difficile TcdA. OA40A protects host cells by blocking the binding of TcdA to cell surfaces. A-C9 exhibited restoration of strong binding to CROP domain and the transmembrane domain (TLD) of TcdA, which is located in epitopes existing between 1410 and 2033 aa. rA-C2 binds to repeating epitopes within LR3 of the CROP domain of TcdA. |
| Reactivity | C. difficile |
| Applications | ELISA; Neut |
| Host | Human |
| Epitope |
OA40A: CROP domain C-terminus A-C9: CROP domain rA-C2: LR3 of the CROP domain |
| Isotype |
OA40A: Humanized IgG1 kappa A-C9; rA-C2: Human IgG1 kappa |
| Clonality | Monoclonal |
| Clone | OA40A; A-C9; rA-C2 |
| Dilutions | ELISA: 0.1-1000 ng/mL |
Properties
| Expression Host | HEK293F/CHO |
| Conjugations | Conjugation could be customized |
| Purification | Protein A/G affinity purified is the regular method |
| Purity | SDS-PAGE> 95% |
| Endotoxin Level | Endotoxin level could be customized |
| Form | Liquid (frequently-used) or lyophilized |
| Concentration | About 1mg/ml. There are differences between batches. Special concentration could be customized. |
| Sterility | 0.2 μM filtered |
| Buffer | See the Datasheet |
| Storage | See the Datasheet |
Target
| Target | C. difficile TcdA |
| Alternative Names | TcdA; Clostridium difficile TcdA; toxin A; C. difficile; Clostridium difficile |
| Introduction | Two homologous exotoxins, toxin A (TcdA, molecular weight: 308 kDa) and toxin B (TcdB, molecular weight: 270 kDa), are major virulence factors of C. difficile, which contain four functional domains, each playing a role in a multi-step mechanism of entry. |
| Organism | Bacteria |
| Related Disease | Clostridium difficile infection and C. difficile-associated disease |
| Infections Route | Oral cavity, skin, alimentary canal |
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