3D Biology Based Pancreatic Endocrine Toxicity Evaluation Service

Pancreatic Endocrine Toxicity

Drug-induced endocrine disruption is one of the most common reasons for safety screening failures in this regard. Endocrine disruptors can interfere with the normal functioning of the endocrine system, leading to hormonal imbalances and adverse effects on various physiological processes.

Traditional Models for Pancreatic Endocrine Toxicity Evaluation

Animal models, commonly used in pancreatic endocrine toxicity evaluation, exhibit differences in pancreatic physiology compared to humans, limiting the translatability of findings to clinical applications. Here, Creative Biolabs proudly provides 3D biology-based pancreatic endocrine toxicity evaluation service that overcomes limitations of traditional model.

Standout Qualities

• Replicating islet cell, hormone, and endocrine component relationships.
• Enhanced predictivity for compound responses in clinical studies.
• Encompasses the assessment of pancreatic endocrine function.

By faithfully recapitulating the intricate interactions amongst pancreatic islet cells, hormones, and other components of the endocrine microenvironment, our model enables prolonged in vitro culturing to ascertain the effects of long-term drug exposure.

Typically, we consider both cell cytotoxicity and β-cell function as pivotal indicators of endocrine activity. Our endpoints for testing encompass:

• Insulin content measurement
• ATP consumption detection
• Glucose-stimulated insulin secretion

Should you desire to incorporate additional endpoints as toxicity evaluation indicators, please do not hesitate to contact our team of experts to discuss your specific requirements.