As a biotechnology company, Creative Biolabs possesses years of experience and expertise, enabling it to offer comprehensive drug discovery and development services. We utilize 3D biology-based models for drug screening, efficacy assessment, and toxicology studies to aid our clients in identifying and developing safer and more effective drugs for metabolic diseases.
Human metabolism refers to the process of transformation and utilization of chemical substances within the body, including energy production and utilization, nutrient intake and metabolism, and hormone synthesis and regulation. Abnormalities in the metabolism of different substances (including metabolic disorders and metabolic overactivity) can lead to various types of metabolic diseases.
Metabolic Abnormality | Representative Diseases | Etiology |
Glucose Metabolism Abnormality |
Diabetes (Type 1 and Type 2) |
Abnormal insulin secretion and utilization lead to elevated blood glucose. |
Hypoglycemia | Excessive insulin secretion or insufficient insulin resistance. | |
Lipid Metabolism Abnormality | Atherosclerosis | High levels of cholesterol and triglycerides in the blood are deposited in the inner walls of blood vessels. |
Fatty Liver (Alcoholic and Non-alcoholic) |
Excessive fat accumulation in the liver leads to impaired liver function. | |
Calcium-Phosphate Metabolism Abnormality | Parathyroid Dysfunction | Abnormal secretion of parathyroid hormones leads to calcium and phosphate metabolism disorders, such as primary and secondary hyperparathyroidism or hypoparathyroidism. |
Osteoporosis | Disruption of calcium-phosphate balance due to increased calcium outflow from bones or increased bone resorption. | |
Purine Metabolism Abnormality | Gout | Elevated uric acid levels lead to uric acid crystal deposition in joints and tissues, causing arthritis and pain. |
Metabolic diseases impose a considerable burden on individuals' health and society's economy. The treatment of these diseases often requires long-term medication, and the effectiveness of drug therapy is limited, with potential side effects and drug resistance issues. Therefore, there is an urgent need to develop more effective metabolic disease drugs to meet patients' treatment needs.
This involves in-depth studies of metabolic pathways, hormone regulation, cell signaling, and other aspects. Therefore, using highly relevant biological models combined with high-throughput screening, genomics, proteomics, and other technological approaches to discover potential therapeutic targets will provide many new opportunities for drug development in metabolic diseases.
Metabolic diseases are complex multifactorial disorders involving multiple targets and pathways, limiting the efficacy of single drugs. Additionally, consideration must be given to drug safety, pharmacokinetics, and drug interactions. As a result, selecting appropriate biological models to develop innovative drug strategies and ensure clinical safety is a current focus of research efforts.
Fig.1 Applications of organoids in metabolic research.1
Our team possesses extensive knowledge, technical expertise, and innovative thinking.
We offer a variety of 3D models, including 3D spheroid models, organoid models, 3D ex vivo tissue models, and more.
We design optimal experimental strategies to ensure the best achievement of research objectives.
Our services encompass drug efficacy assessment, toxicity evaluation, pharmacokinetics studies, and more.
Whether you require specific experimental services or comprehensive drug development support, Creative Biolabs can provide you with high-quality services and professional advice. Contact us now to accelerate your metabolic disease drug discovery and development projects!
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