Organ-on-a-Chip Model Introduction

Creative Biolabs is a leading biotechnology company that offers cutting-edge solutions for drug discovery and development. We have a team of experienced scientists who specialized in the 3D biology field. Our experts endeavor to deliver a comprehensive selection of customized organ-on-a-chip (OOC) models, all carefully designed to meet your specific research needs and facilitate the remarkable achievement of your project.

Fig 1. Multi-organ chip platform for disease modeling. (Danku, 2022)

Key Features of Organ-on-a-chip Models

The OOC is an intriguing scientific and technological development that comprises advanced in vitro technology that enables experimentation with biological cells and tissues outside the body. Here, we present a comprehensive overview of the distinct characteristics of OOCs and conventional 2D cell cultures, offering a transparent perspective on the unique benefits of OCCs.

Parameter	Organ-on-chip	Conventional 2D systems
Cell morphology	Size and shape similar to in vivo case	Unnatural
Production characteristics	Multiple relevant cell types seeded into engineered chambers with perfusion and/or biomechanical forces included	Grown on rigid flat surfaces, often as a cellularly homogeneous monolayer
Production complexity and speed	Days to weeks (depending on cell sources and required tissue maturation metrics)	Generally straightforward and fast (hours to days)
*Maturation of iPS cell-derived cells allowed by platform**	Platform designs can improve and encourage cell maturity	Immature
Level of control over cell architecture	High	High
Diffusion of signal factors and nutrients	Allows precisely controlled temporal and spatial gradients	Short distances possible
Vascularization or perfusion	By microfluidic channels or design which can include/create endothelialized vessels	Not possible, generally perfusion via medium change
High-throughput feasibility	Depends on platform design, generally low to medium throughout	Yes
On-platform assay and analysis difficulty	Real-time tissue/organ function analyses possible	Low difficulty, easy access to cells and readouts
*Variability and in vivo* relevance**	Low variability and high relevance	Low variability and relevance

*iPS cell: induced pluripotent stem cell.

Applications

OOC models have emerged as a promising tool for drug discovery, toxicity testing, disease modeling, and personalized medicine. These microfluidic devices are designed to mimic the complex biological functions of human organs, providing a more accurate and reliable platform for drug screening and development. Additionally, OOC models can be used to study disease mechanisms and develop targeted therapies, potentially revolutionizing the field of precision medicine.

What Do We Offer?

Our organ-on-a-chip models are developed with an intended application in mind, who will be able to offer you services such as testing biomaterials, predicting compound efficacy and side effects, mimicking the complexity of normal or diseased states in humans for biological research. They are also well suited for applying a range of physical environmental stimuli on cells.

Single Organ-on-a-chip Model Multiple Organs-on-a-chip Model Barrier Tissue-on-a-chip Model Disease-on-a-chip Model Customized Tissue-on-a-chip Model

Building upon the foundation of established organ-on-a-chip models, Creative Biolabs has launched a range of supporting services outlined below, showcasing our dedication to providing pioneering solutions in 3D biology studies. Talk to our experts to learn more about our organ-on-a-chip models and how they can benefit your research.

Reference

Danku, A.; et al. Organ-on-a-chip: a survey of technical results and problems. Front. Bioeng. Biotechnol. 2022, 10: 840674.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays

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Research Model

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