3D Biology Based Ocular Disease Drug Discovery and Development

Creative Biolabs is a professional biotechnology service company offering 3D biology-based drug discovery and development services for ocular disease research. By utilizing advanced 3D biologic model technologies, we can more realistically simulate the structure and functionality of human ocular tissues, allowing for more accurate research into the pathogenesis of ocular diseases or the evaluation of candidate drugs' efficacy and safety.

Ocular Diseases Treatment is Facing a Bottleneck

Causative Factors：	Types of Ocular Disease:
Aging Increased use of electronic devices Environmental pollution Light pollution Unhealthy lifestyle habits Genetic factors ……	Macular degeneration Glaucoma Cataracts Retinal disorders ……

Fig.1 The anatomy of the human adult eye.¹

Malformations or functional impairments in different tissues of the eyes can severely damage visual function and potentially lead to blindness. However, the current treatment methods for ocular diseases are subject to various limitations:

Complexity and Diversity

The eyes are complex organs involving the coordination of multiple tissues and the nervous system. Different ocular diseases may involve different mechanisms, but our current understanding of these aspects remains insufficiently comprehensive and in-depth.

Lack of Effective Research Models

Due to biological differences between species, animal models cannot fully replicate human organ development and pathological processes, limiting the translation of basic research findings to clinical applications.

Challenges in Local Treatment

The eyes are highly complex and sensitive organs, making local treatment often challenging. For example, the retention time of drugs on the eye surface may be limited, making it difficult to achieve sufficient therapeutic concentrations.

Safety and Side Effects

The development of new drugs and treatment methods requires careful consideration of their safety and side effects, especially concerning eye-related treatments, to avoid irreversible damage to visual function.

Indispensable 3D Human Ocular Models

The limitations highlight the need for the development of 3D human ocular models to more accurately simulate the development and treatment processes of ocular diseases in humans. Such models will contribute to a deeper understanding of the mechanisms of ocular diseases and provide stronger support for the development of more effective and safe treatment methods.

3D Ocular Spheroid Model:

This model uses specific types of ocular cells as seed cells, under specific culture conditions and support matrices, and forms a spherical structure to simulate the interactions and physiological functions of specific ocular cells in the body.

Ocular Tissue Organoid Model:

This model uses human-derived cells that are induced and cultured under specific conditions to self-assemble into structures and functionalities resembling real ocular tissues, such as the cornea, lens, retina, lacrimal gland, etc.

Application of 3D Human Ocular Model

Ocular developmental studies:	Disease mechanism studies:	Drug screening and evaluation:
Through 3D human ocular models, researchers can simulate the formation and differentiation of different tissues during ocular development. This allows for in-depth investigations of key processes involved in eye development, such as signaling pathways, gene expression regulation, and cell fate determination.	This model provides a more realistic research platform for simulating the pathological processes and pathogenesis of various ocular diseases. It offers essential clues for developing treatments and new drugs targeting specific diseases.	Researchers can conduct drug screening and rapidly assess the effects of different drugs on ocular tissues. The drug testing results obtained are more relevant to human situations, helping to discover more effective and safe treatment methods.

Fig.2 Age-related macular degeneration model derived iPSC cells for drug discovery.2

Creative Biolabs Service Highlights

A team of experienced scientists and professional researchers
Diverse 3D human ocular models
Advanced technological platforms
Customized services
Comprehensive solutions

As a leading company dedicated to the field of biotechnology, we are committed to providing the highest quality services and cutting-edge technologies to meet your needs in ocular disease drug discovery and development. Our services go beyond delivering top-notch scientific research; we aim to establish long-term partnerships and work together with you to achieve outstanding research outcomes. Therefore, we sincerely invite you to contact us.

References

Kaluzhny, Y.; Klausner, M. In vitro reconstructed 3D corneal tissue models for ocular toxicology and ophthalmic drug development. In Vitro Cellular and Developmental Biology. Animal.2021, 57(2): 207-237.
Boutin, M.E.; et al. 3D engineering of ocular tissues for disease modeling and drug testing. Advances in Experimental Medicine and Biology. 2019, 1186: 171-193.

Research Model

3D Biology Based Biomarker Discovery

3D Biology Based Drug Discovery and Development

3D Biology Based Toxicity Evaluation

Supporting Assays

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