3D Biology Based Musculoskeletal Disease Drug Discovery and Development

Why Develop New Drugs for Musculoskeletal Diseases (MDs)?

When the musculoskeletal system (MS) is damaged or diseased, it can severely impact the normal functions of the human body and, in severe cases, lead to disability. Bone tissue engineering is a widely used approach for bone/cartilage repair, where bioactive scaffold materials loaded with seed cells can promote bone/cartilage regeneration. However, it has some limitations:

• Lacking in vitro models that closely resemble the characteristics of human bone tissue.
• The process of scaffold material and seed cell selection relies on in vivo testing, which is time-consuming and costly.

To address the limitations of traditional bone tissue engineering and assist clients in identifying critical targets for MD treatment and evaluating the therapeutic effects of candidate drugs, Creative Biolabs offers 3D biology-based drug discovery and development services for MDs.

What is a 3D Musculoskeletal System Biology Model (3D MSBM)?

The 3D MSBMs refer to a model constructed using three-dimensional in vitro culture techniques to simulate the structure and function of the human MS. This model utilizes cell culture, tissue engineering, and bioprinting technologies to assemble human bone and muscle cells or tissues into a three-dimensional structure, allowing for research and experimentation that closely mimic the physiological environment inside the body.

Fig.1 A schematic figure of biofabrication technique for bone organoid.¹

Types of 3D MSBMs

Advantages of 3D MSBMs

The aforementioned 3D MSBMs have created a novel platform for studying MDs and conducting new drug screenings. 3D MSBMs have many advantages:

Developmental Mechanism Research Platform

These models can simulate the developmental processes of musculoskeletal tissues, aiding researchers in understanding the formation and interactions of different tissues. This helps uncover regulatory mechanisms and molecular signaling involved in development.

Disease Pathology Research Platform

By constructing disease-relevant 3D biology models, the development and pathological features of diseases can be simulated. This assists scientists in gaining a better understanding of disease mechanisms and provides new insights and strategies for disease treatments.

Cell Biology Research Platform

These models offer a more physiologically relevant in vitro environment for studying cellular behaviors and interactions in three-dimensional settings. This facilitates a deeper understanding of cell functions and regulatory mechanisms.

Musculoskeletal Repair Research Platform

Using organoid technology to cultivate populations of stem cells can replace damaged or diseased normal cells, enabling tissue regeneration and repairment. This provides new therapeutic approaches and possibilities in the field of regenerative medicine.

Drug Screening and Evaluation Platform

Utilizing these models allows for more realistic drug toxicity and efficacy testing, reducing reliance on animal models and providing more accurate data for drug development.

Bone Biomaterial Repairment Evaluation Platform

These models enable high-throughput screening of bone biomaterials required for bone tissue engineering in vitro, facilitating the rapid selection of superior materials. This expedites the development and promotion of bone biomaterials.

Creative Biolabs is dedicated to the application of cutting-edge technologies and 3D MSBMs, to provide efficient, reliable, and comprehensive drug and repairment material evaluation and screening services to clients. This advanced technology helps clients discover superior drugs quickly and accelerates the treatment process of MDs. If you are seeking innovative solutions for MD drug discovery, feel free to contact us.

Related Sections:

• 3D Biology Based Immuno-Oncology Drug Discovery and Development
• 3D Biology Based Neurological Disorder Drug Discovery and Development
• 3D Biology Based Inflammation & Immunological Disease Drug Discovery and Development
• 3D Biology Based Metabolic Disease Drug Discovery and Development
• 3D Biology Based Urological System Disease Drug Discovery and Development
• 3D Biology Based Digestive System Disease Drug Discovery and Development
• 3D Biology Based Ocular Disease Drug Discovery and Development