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3D Human Cortical Spheroid Model Introduction

Deviations and afflictions targeting the human cortex engender impairments in cognition and instigate neurological disorders. Such conditions have the potential to disrupt the customary operation of the cortex, giving rise to afflictions such as memory deficits, motor impairments, and seizures. Creative Biolabs proudly presents our 3D human cortical spheroid model, an advanced experimental tool meticulously designed to meet your research needs.

Differentiation of oligodendrocytes in human cortical spheroids. (Madhavan,2018)

Traditional Models for Cortical Research

Conventional cellular models completely overlook the role of the 3D microenvironment in physiological and pathological processes. Moreover, most neurodevelopmental disorders display genetic heterogeneity among patients, which limits the applicability of in vitro models in relevant research, particularly in targeted drug development. Rodent models recapitulate certain pathological processes, but the histological and biological differences between species render many experimental findings unable to translate into mature and effective clinical tests.

Why Choose Creative Biolabs 3D Human Cortical Spheroid Model

Creative Biolabs has developed stable and flexible differentiation methods and standardized operating protocols to simulate the required cell proliferation, tissue organization, and maturation stages of the human cerebral cortex, enabling large-scale differentiation experiments and disease modeling with the following advantages.

  • IPSCs-derived organoids recapitulate the cellular architecture of the human brain and study the biological mechanisms underlying neurodegenerative disorders.
  • Using patient-derived cells, these organoids provide a means to simulate brain diseases within a genetic context and facilitate drug testing.
  • The differentiation of pluripotent stem cells in 3D cultures captures key aspects of brain development and disease onset with extended temporal dynamics.

Neural and vascular marker expression of hybrid spheroids. (Song, 2019)

What We Provide

Creative Biolabs specializes in providing highly reliable and consistent models for any brain disease research, supporting long-term in vitro differentiation experiments, single-cell analysis, transcriptomic profiling, immunocytochemistry, and other downstream assessment procedures. In addition to 3D human cortical spheroid model, you may also be interested in:

Our Services

Expanding upon our extensive range of 3D spheroid models, our experienced team is fully capable of providing tailored solutions to meet our clients’ specific requirements empowered by a series of 3D biology-based assay services. Please feel free to contact us to explore the exciting possibilities that we offer.

References

  1. Madhavan, M.; et al. Induction of myelinating oligodendrocytes in human cortical spheroids. Nat Methods. 2018, 15(9): 700-706.
  2. Song, L.; et al. Assembly of human stem cell-derived cortical spheroids and vascular spheroids to model 3-D brain-like tissues. Nature. 2019, 9: s41598.
Research Model
3D Biology Based Biomarker Discovery
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3D Biology Based Drug Discovery and Development
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3D Biology Based Toxicity Evaluation
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